Module
- Number
- 268
- Regulatory Genes
- 1
- Module Genes
- 4
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
---|---|---|---|---|---|
flh-1 | Y11D7A.12 | WBGene00012435 | 178 | View |
CLR Predictions
7 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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aly-2 | F23B2.6 | WBGene00000121 |
aly-2 encodes an RRM motif-containing protein required for normal export of TRA-1/tra-2 mRNA complexes, and thus for normal hermaphroditism; ALY-2 is orthologous to human THOC4 (OMIM:604171), and paralogous to ALY-1 and ALY-3; in the absence of TRA-1, and in conjunction with NXF-1, ALY-2 and its paralog ALY-1 are required to bind the TRE 3' UTR element of tra-2 mRNA, and block tra-2 mRNA's export from the nucleus; aly-2(RNAi) animals have abnormal female (as opposed to hermaphrodite) sexual phenotypes; by orthology, ALY-2 is thought to promote recruitment of mRNA export factor to mRNAs; other than these sex-determination phenotypes, ALY-2 has no grossly obvious function in four-way RNAi assays of ALY-1/-3 and W04D2.6.
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F54D7.6 | F54D7.6 | WBGene00023067 | View | |
htz-1 | R08C7.3 | WBGene00019947 |
htz-1 encodes the C. elegans ortholog of the H2A.Z histone variant; htz-1 is an essential gene and during development, HTZ-1 functions with the PHA-4/FoxA transcription factor and the MYS-1/TIP60-SSL-1/SWR1 remodeling complex to regulate gene expression during pharyngeal (foregut) organogenesis; a YFP::HTZ-1 fusion protein localizes to pharyngeal gene promoters at the onset of transcription, in a manner that requires PHA-4.
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iff-1 | T05G5.10 | WBGene00002064 |
iff-1 encodes an eIF-5A homolog that affects fertility and is required for germ cell proliferation and for some P granule components to localize properly; expression is germline specific and mRNA is expressed in the distal region of gonads where germ cells actively proliferate.
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