tag-279
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F18E9.5 |
WBGene00017571 |
F18E9.5 encodes, by alternative splicing, two isoforms of a histone H3 trimethyllysine-27 (H3K27me3) demethylase that is required for normal gonad migration and organization; F18E9.5 protein demethylates H3K27me3 in vitro; F18E9.5 contains an N-terminal TonB domain and a C-terminal JmjC domain, and is homologous to human JMJD3, UTX (OMIM:300128), and UTY (OMIM:400009); null F18E9.5(gk384) and F18E9.5(gk387) mutants have aberrant gonad migration and disordered diakinesis-phase oocytes, phenotypes enhanced at 25 deg. C.; F18E9.5 is expected to antagonize transcriptional repression by polycomb repressor complexes, which mark stem cells (and presumably germline) by H3K27me3-mediated repression of somatic genes.
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