Module
- Number
- 187
- Regulatory Genes
- 5
- Module Genes
- 11
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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sta-1 | Y51H4A.17 | WBGene00013111 | 524 |
sta-1 encodes the C. elegans STAT orthologue; from N- to C-terminus, STA-1 contains conserved coiled-coil, DNA-binding, and SH2 domains, but apparently lacks a conserved amino-terminal oligomerization domain found in other STAT family members; sta-1 activity is required for repressing dauer formation at high temperatures and genetic analyses indicate that STA-1 acts redundantly with some members of the DAF-7/TGF-beta signaling pathway to repress dauer formation, particularly at low temperatures; tyrosine-phosphorylated STA-1 is able to bind a high affinity mammalian STAT binding sequence, and the STA-1 C-terminus can function as a transcriptional activation domain; sta-1 is widely expressed during most life stages, including the dauer stage, and is found in the pharynx, intestine, body wall muscles, and in neurons; STA-1 localizes to both the cytoplasm and the nucleus, with expression in the latter found particularly in some amphid neurons; in some neurons, STA-1 expression appears to be negatively regulated by DAF-7/TGF-beta signaling.
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nhr-56 | F44C8.6 | WBGene00003646 | 153 |
nhr-56 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators; nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain.
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hbl-1 | F13D11.2 | WBGene00001824 | 137 |
hbl-1 encodes a protein that contains nine putative zinc finger domains of the C2H2 type and affects embryonic viability, locomotion, egg laying, body morphology, and hypodermal differentiation; expressed in hypodermal precursor cells, neuronal precursor cells, and pharyngeal cells during embryogenesis and is primarily expressed in neurons during larval development.
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T24F1.3 | T24F1.3 | WBGene00011995 | 130 | View | |
nhr-109 | T12C9.5 | WBGene00003699 | 116 |
nhr-109 encodes a nuclear receptor that is most highly conserved amongst nematode species.
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CLR Predictions
35 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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C17G1.5 | C17G1.5 | WBGene00007652 | View | |
C45B11.6 | C45B11.6 | WBGene00045379 | View | |
cutl-16 | K06A1.3 | WBGene00019426 | View | |
F32D1.3 | F32D1.3 | WBGene00017983 | View | |
F48E3.8 | F48E3.8 | WBGene00018607 | View | |
K02E10.6 | K02E10.6 | WBGene00019320 | View | |
mec-6 | W02D3.3 | WBGene00003170 |
mec-6 is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease; MEC-6 protein interacts physically with the MEC-4 degenerin ion channel, is colocalized with it in vivo, and is required for MEC-4 punctate expression along touch-receptor neural processes.
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mnm-2 | C10A4.8 | WBGene00003380 | View | |
nhr-203 | M02H5.5 | WBGene00019743 | View | |
T25B9.3 | T25B9.3 | WBGene00012009 | View | |
Y40C5A.4 | Y40C5A.4 | WBGene00021497 | View |