Module
- Number
- 160
- Regulatory Genes
- 5
- Module Genes
- 8
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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H32C10.3 | H32C10.3 | WBGene00019257 | 490 | View | |
rap-3 | C08F8.7 | WBGene00004309 | 264 | View | |
spe-10 | AC3.10 | WBGene00004964 | 156 | View | |
nhr-4 | F32B6.1 | WBGene00003603 | 140 |
nhr-4 is predicted to encode a nuclear hormone receptor (NHR); expression may peak during the late larval stages, based on mRNA expression analysis.
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skn-1 | T19E7.2 | WBGene00004804 | 104 |
skn-1 encodes a transcription factor with similarity to the basic region of bZip transcription factors; during early embryogenesis, maternally provided SKN-1 is required for specification of the EMS blastomere, a mesendodermal precursor that gives rise to pharyngeal, muscle, and intestinal cells; later, during postembryonic development, SKN-1 functions in the p38 MAPK pathway to regulate the oxidative stress response and in parallel to DAF-16/FOXO in the DAF-2-mediated insulin/IGF-1-like signaling pathway to regulate adult lifespan; in vitro assays indicate that SKN-1 can be directly phosphorylated by the AKT-1, AKT-2, and SGK-1 kinases that lie downstream of DAF-2 in the insulin signaling pathway and in vivo experiments suggest that this phosphorylation is essential for regulation of SKN-1 nuclear accumulation and hence, transcriptional regulator activity; in the early embryo, SKN-1 is detected at highest levels in nuclei of the P1 blastomere and its descendants through the 8-cell stage of embryogenesis; later in embryogenesis, SKN-1 is observed in all hypodermal and intestinal nuclei, with reporter constructs indicating that intestinal expression begins as early as the 50-100-cell stage; in larvae and young adults, SKN-1::GFP reporters are expressed in the intestine and ASI neurons, with expression in intestinal nuclei enhanced under conditions of stress or reduced DAF-2 signaling.
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CLR Predictions
None
Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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C08F8.4 | C08F8.4 | WBGene00007446 | View | |
F42G4.2 | F42G4.2 | WBGene00009641 | View | |
F45E4.6 | F45E4.6 | WBGene00018471 | View | |
T21G5.1 | T21G5.1 | WBGene00020659 | View | |
wht-6 | T26A5.1 | WBGene00007060 | View | |
Y42H9AR.2 | Y42H9AR.2 | WBGene00021537 | View | |
Y46H3D.1 | Y46H3D.1 | WBGene00021608 | View | |
Y57G7A.6 | Y57G7A.6 | WBGene00021969 | View |