Module
- Number
- 153
- Regulatory Genes
- 4
- Module Genes
- 11
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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sex-1 | F44A6.2 | WBGene00004786 | 578 |
sex-1 encodes a DNA-binding protein that is a member of the nuclear hormone receptor superfamily of transcriptional regulators; during embryonic development, SEX-1 functions as an X chromosome signal element that transmits the primary sex-determination signal by negatively regulating transcription of xol-1, a gene whose expression levels correlate with hermaphrodite or male development (low xol-1 levels result in hermaphrodite development, high xol-1, in that of males); in vivo, SEX-1 can associate with extrachromosomal arrays containing the xol-1 promoter, indicating that SEX-1's affect on xol-1 transcription is likely to be direct; SEX-1 localizes to nuclei from oogenesis through mid-embryogenesis, with highest levels of expression visible during early gastrulation (28-100-cell-stage); the SEX-1 expression pattern appears to be similar in hermaphrodites and males.
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Y82E9BR.17 | Y82E9BR.17 | WBGene00022349 | 462 | View | |
cdc-14 | C17G10.4 | WBGene00000383 | 124 |
cdc-14 encodes a dual-specificity phosphatase, homologous to Cdc14p in S. cerevisiae; CDC-14 localizes to the central spindle in anaphase and to the midbody in telophase, and is required for cytokinesis and embryonic viability.
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eya-1 | C49A1.4 | WBGene00001377 | 107 |
eya-1 encodes a protein orthologous to the Eyes absent/Eya Drosophila protein which is involved in eye development and has protein tyrosine phosphatase ; RNA interference and mutant studies indicate that eya-1 is involved in embryonic and larval tissue morphogenesis as well as larval viability; eya-1 mutants show increased embryonic cell deaths due to activation of the cell death pathway; eya-1 functions redundantly with vab-3/eyeless to control larval viability and anterior body morphogenesis; GFP studies show that eya-1 is expressed in a subset of nuclei during embryonic morphogenesis; the human genes EYA1 and EYA4, when mutated, lead to disease syndromes.
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CLR Predictions
50 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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bath-9 | Y49F6C.3 | WBGene00021725 | View | |
C40A11.2 | C40A11.2 | WBGene00016545 | View | |
C40A11.6 | C40A11.6 | WBGene00016549 | View | |
F48E3.6 | F48E3.6 | WBGene00018606 | View | |
F53G2.1 | F53G2.1 | WBGene00018766 | View | |
fbxc-24 | R07C3.11 | WBGene00019927 | View | |
fbxc-29 | R07C3.7 | WBGene00019923 | View | |
fbxc-34 | R07C3.5 | WBGene00019921 | View | |
T02C1.1 | T02C1.1 | WBGene00011365 | View | |
T11B7.1 | T11B7.1 | WBGene00011706 | View | |
Y41D4A.3 | Y41D4A.3 | WBGene00021505 | View |