Module
- Number
- 140
- Regulatory Genes
- 5
- Module Genes
- 11
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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nhr-2 | C32F10.6 | WBGene00003601 | 905 |
nhr-2 encodes a member of the nuclear hormone receptor family that is required for embryonic viability and morphogenesis; expressed during embryogenesis.
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ceh-40 | F17A2.5 | WBGene00000461 | 283 |
ceh-40 encodes one of two C. elegans homeodomain proteins homologous to Extradenticle (Exd/Pbx); ceh-40 genetically interacts with ceh-20 and unc-62 during embryonic development: while loss of ceh-40 activity alone results in no significant embryonic lethality, loss of ceh-40 and ceh-20, or ceh-40, ceh-20, and unc-62, results in incompletely penetrant embryonic lethality.
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tra-4 | F53B3.1 | WBGene00018740 | 162 | View | |
cep-1 | F52B5.5 | WBGene00000467 | 115 |
cep-1 encodes an ortholog of the human tumor suppressor p53 (OMIM:191170, mutated in Li-Fraumeni syndrome) that promotes DNA damage-induced apoptosis and is required for normal meiotic segregation in the germ line, and affects sensitivity to hypoxia-induced lethality and longevity in response to starvation; CEP-1 is expressed ubiquitously in embryos and in the nucleoli of a subset of pharyngeal cells.
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sex-1 | F44A6.2 | WBGene00004786 | 112 |
sex-1 encodes a DNA-binding protein that is a member of the nuclear hormone receptor superfamily of transcriptional regulators; during embryonic development, SEX-1 functions as an X chromosome signal element that transmits the primary sex-determination signal by negatively regulating transcription of xol-1, a gene whose expression levels correlate with hermaphrodite or male development (low xol-1 levels result in hermaphrodite development, high xol-1, in that of males); in vivo, SEX-1 can associate with extrachromosomal arrays containing the xol-1 promoter, indicating that SEX-1's affect on xol-1 transcription is likely to be direct; SEX-1 localizes to nuclei from oogenesis through mid-embryogenesis, with highest levels of expression visible during early gastrulation (28-100-cell-stage); the SEX-1 expression pattern appears to be similar in hermaphrodites and males.
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CLR Predictions
56 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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btb-6 | F45C12.7 | WBGene00018438 | View | |
F15B10.3 | F15B10.3 | WBGene00017481 | View | |
F54D5.5 | F54D5.5 | WBGene00010051 | View | |
F59C12.4 | F59C12.4 | WBGene00045272 | View | |
R11.4 | R11.4 | WBGene00011229 | View | |
R11A5.3 | R11A5.3 | WBGene00011231 | View | |
skr-10 | Y105C5B.13 | WBGene00004816 |
skr-10 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-10 is required for posterior body morphogenesis, embryonic and larval development, and cell proliferation; SKR-10 is expressed in the tip and end regions of the intestine and can interact in vivo with CUL-1 and CUL-2, C. elegans cullin homologs.
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skr-14 | Y47D7A.8 | WBGene00004820 |
The skr-14 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-14(RNAi) animals are at least superficially normal.
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skr-15 | F54D10.1 | WBGene00004821 |
The skr-15 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-15(RNAi) animals are at least superficially normal.
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T05H10.4 | T05H10.4 | WBGene00011509 | View | |
T16G12.4 | T16G12.4 | WBGene00011805 | View |