Module
- Number
- 124
- Regulatory Genes
- 3
- Module Genes
- 12
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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T26A5.8 | T26A5.8 | WBGene00020823 | 402 | View | |
ccch-5 | Y57G11C.25 | WBGene00013319 | 154 |
Y57G11C.25 encodes a CCCH tandem zinc finger (TZF) protein; based upon its sequence similarity to C. elegans POS-1, the product of Y57G11C.25 is predicted to function as an RNA-binding protein.
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Y43C5A.2 | Y43C5A.2 | WBGene00012782 | 134 | View |
CLR Predictions
8 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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act-3 | T04C12.4 | WBGene00000065 |
act-3 encodes an invertebrate actin, highly similar to ACT-1, ACT-2, and ACT-4, that functions in body wall muscle; act-3 functions with two other action isoforms, act-1 and act-2, to control cytoplasmic microfilament function in the early embryo.
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cco-1 | F26E4.9 | WBGene00000371 | View | |
ctb-1 | MTCE.21 | WBGene00000829 |
The ctb-1 gene resides on the mitochondrial chromosome, and encodes the cytochrome b protein of mitochondrial complex III; mutation of ctb-1 suppresses the slow embryonic development of isp-1 mutants, while enhancing their paraquat resistance.
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dlc-1 | T26A5.9 | WBGene00001005 |
dlc-1 encodes a dynein light chain 1, required for viability, that inhibits DHC-1 in vivo; DLC-1 is 92-95% identical to its orthologs human DYNLL1 (OMIM:601562) and DYNLL2 (OMIM:608942); DLC-1 is paralogous to DLC-2/-6; DLC-1 is expressed in adult body wall muscle, and in larval and adult pharynx, posterior intestine, and nervous system (e.g., ventral nerve cord, head neurons, and tail neurons); dlc-1 is probably transcriptionally activated by DAF-19; DLC-1 is required for normal embryonic and larval viability, embryonic pronuclear migration, growth speed, fertility, brood size, body shape, and cuticular integrity.
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F32D1.2 | F32D1.2 | WBGene00017982 | View | |
MTCE.11 | MTCE.11 | WBGene00010959 | View | |
R53.4 | R53.4 | WBGene00011273 | View | |
ran-1 | K01G5.4 | WBGene00004302 |
ran-1 encodes the C. elegans Ran GTPase ortholog; ran-1 activity is essential for proper mitotic spindle formation, effective connection between centrosomes and the male pronucleus, nuclear envelope assembly after cell division, and oocyte meiotic maturation; in regulating nuclear envelope dynamics, ran-1 appears to function upstream of MEL-28 by regulating its localization to the nuclear periphery; in regulating oocyte meiotic maturation, RAN-1 interacts with VAB-1 MSP/Eph and regulates its localization to endocytic-recycling vesicles in the absence of the major sperm protein (MSP)/sperm; in dissected gonads and oocytes, RAN-1 staining is detected at the cortex.
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ril-1 | C53A5.1 | WBGene00008262 | View | |
tag-174 | F54D8.2 | WBGene00006519 | View | |
tbb-1 | K01G5.7 | WBGene00006536 |
This gene encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-1 is redundant for embryonic viability, due to its paralog TBB-2.
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tbb-2 | C36E8.5 | WBGene00006537 |
tbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is preferred for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis.
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