Module
- Number
- 120
- Regulatory Genes
- 4
- Module Genes
- 12
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
---|---|---|---|---|---|
rab-1 | C39F7.4 | WBGene00004266 | 185 |
rab-1 encodes an ortholog of the small Ras-like GTPase Rab1; by homology, RAB-1 is predicted to play a role in intracellular vesicle trafficking, and consistent with this broad role, large-scale RNAi screens indicate that rab-1 activity is required for fertility, movement, and survival; in yeast two-hybrid assays, RAB-1 interacts with TIR-1, a C. elegans SARM ortholog that is required for innate immunity; RNAi studies suggest that RAB-1 and TIR-1 likely function in a pathway that controls expression of antimicrobial peptides such as NLP-29 and NLP-31; rab-1 also appears to play a role in regulating polyglutamine protein aggregation, as rab-1(RNAi) animals show premature accumulation of protein aggregates; in situ hybridization studies indicate that rab-1 is broadly expressed, with elevated levels apparent in the germline.
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srg-4 | T12A2.12 | WBGene00005162 | 184 | View | |
srg-44 | F31E9.2 | WBGene00005201 | 177 | View | |
nhr-209 | R07B7.16 | WBGene00011100 | 121 | View |
CLR Predictions
None
Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
---|---|---|---|---|
C24H10.3 | C24H10.3 | WBGene00016069 | View | |
C54G7.1 | C54G7.1 | WBGene00016933 | View | |
clec-44 | R07C3.12 | WBGene00019928 | View | |
F47C12.7 | F47C12.7 | WBGene00018550 | View | |
mys-4 | C34B7.4 | WBGene00007914 |
C34B7.4 encodes a MYST family histone acetyltransferase; based upon sequence similarity, the product of C34B7.4 is predicted to be the enzymatic component of an NuA4-like histone acetyltransferase (HAT) complex that functions in transcriptional activation; C34B7.4 is likely required for regulating gene expression in multiple tissues, as loss of its activity via RNAi results in suppression of ectopic lag-2 reporter expression seen in intestinal tissue in SynMuv B mutants as well as in some suppression of the lin-15AB SynMuv phenotype.
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rdy-2 | F53F4.6 | WBGene00004328 | View | |
srb-19 | C54F6.11 | WBGene00016928 | View | |
sri-10 | C54E10.4 | WBGene00005522 | View | |
T02D1.4 | T02D1.4 | WBGene00011371 | View | |
twk-35 | F31D4.7 | WBGene00006687 | View | |
Y47D7A.10 | Y47D7A.10 | WBGene00021622 | View | |
Y67D8B.2 | Y67D8B.2 | WBGene00022062 | View |