Module
- Number
- 116
- Regulatory Genes
- 3
- Module Genes
- 17
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
---|---|---|---|---|---|
sex-1 | F44A6.2 | WBGene00004786 | 1224 |
sex-1 encodes a DNA-binding protein that is a member of the nuclear hormone receptor superfamily of transcriptional regulators; during embryonic development, SEX-1 functions as an X chromosome signal element that transmits the primary sex-determination signal by negatively regulating transcription of xol-1, a gene whose expression levels correlate with hermaphrodite or male development (low xol-1 levels result in hermaphrodite development, high xol-1, in that of males); in vivo, SEX-1 can associate with extrachromosomal arrays containing the xol-1 promoter, indicating that SEX-1's affect on xol-1 transcription is likely to be direct; SEX-1 localizes to nuclei from oogenesis through mid-embryogenesis, with highest levels of expression visible during early gastrulation (28-100-cell-stage); the SEX-1 expression pattern appears to be similar in hermaphrodites and males.
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K10B3.5 | K10B3.5 | WBGene00019611 | 158 | View | |
flh-3 | Y11D7A.13 | WBGene00012436 | 106 | View |
CLR Predictions
103 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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B0281.5 | B0281.5 | WBGene00015112 | View | |
C08F1.6 | C08F1.6 | WBGene00015610 | View | |
C17E4.2 | C17E4.2 | WBGene00007642 | View | |
C39B5.2 | C39B5.2 | WBGene00016520 | View | |
C40A11.4 | C40A11.4 | WBGene00016547 | View | |
ceh-40 | F17A2.5 | WBGene00000461 |
ceh-40 encodes one of two C. elegans homeodomain proteins homologous to Extradenticle (Exd/Pbx); ceh-40 genetically interacts with ceh-20 and unc-62 during embryonic development: while loss of ceh-40 activity alone results in no significant embryonic lethality, loss of ceh-40 and ceh-20, or ceh-40, ceh-20, and unc-62, results in incompletely penetrant embryonic lethality.
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clec-196 | F26D10.12 | WBGene00009156 | View | |
F23D12.5 | F23D12.5 | WBGene00009089 |
F23D12.5 encodes a putative histone H3 di/trimethyllysine-27 (H3K27me2/me3) demethylase; F23D12.5 contains a C-terminal JmjC domain, and is homologous to human JMJD3, UTX (OMIM:300128), and UTY (OMIM:400009); F23D12.5 is expected to antagonize transcriptional repression by polycomb repressor complexes, which mark stem cells (and presumably germline) by H3K27me3-mediated repression of somatic genes; however, F23D12.5 has no obvious function in mass RNAi assays.
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F33E11.6 | F33E11.6 | WBGene00018013 | View | |
F46E10.2 | F46E10.2 | WBGene00018489 | View | |
fbxc-18 | C32B5.14 | WBGene00016307 | View | |
fbxc-36 | R07C3.2 | WBGene00019918 | View | |
fbxc-51 | Y46B2A.1 | WBGene00021576 | View | |
T04B8.3 | T04B8.3 | WBGene00020205 | View | |
T25E12.6 | T25E12.6 | WBGene00012021 | View | |
Y55B1BR.3 | Y55B1BR.3 | WBGene00021913 | View | |
ZK1053.4 | ZK1053.4 | WBGene00014199 | View |