Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

grk-2  

Sequence Name

W02B3.2  

WB ID

WBGene00001709  

Description

grk-2 encodes a serine/threonine protein kinase that is most closely related to G protein-coupled receptor (GPCR) kinases; in C. elegans, grk-2 activity is required in chemosensory neurons for normal calcium influx during chemosensation, but is not required for GPCR downregulation; in regulating chemosensation, GRK-2 likely acts upstream of the ODR-3/G alpha protein, as overexpression of ODR-3 can rescue abnormal avoidance behavior in grk-2 mutants; GRK-2 is broadly expressed in the adult nervous system, with expression beginning as early as the 20-30-cell stage of embryonic development and continuing into adulthood.