Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

bus-17  

Sequence Name

ZK678.8  

WB ID

WBGene00044630  

Description

bus-17 encodes a putative GT13 glycosyltransferase whose homologs include human B3GALT2 (OMIM:603018) and C. elegans BRE-5; BUS-17 is required for bacterial infection, as well as for cuticle integrity, long-term survival, and traction during movement; specifically, bus-17 is needed both for colonization by Microbacterium nematophilum (and the tail-swelling response to M. nematophilum infection) and for attachment of Yersinia pseudotuberculosis biofilms; bus-17 is also needed for normal cuticle antigens; BUS-17 is predicted to have an N-terminal signal sequence and a moderately conserved active site; bus-17 and bus-3 function together in vivo, since bus-17(e2695)/+ sometimes shows nonallelic noncomplementation with bus-3(e2696)/+; bus-17 males are sometimes wild-type if their fathers were wild-type.