Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

alx-1  

Sequence Name

R10E12.1  

WB ID

WBGene00007010  

Description

alx-1 encodes one of two C. elegans Bro1 domain-containing proteins; during development, ALX-1 functions in the regulation of protein trafficking via endocytic recycling of clathrin-independent cargo and membrane-protein degradation; ALX-1 physically interacts with RME-1, a component of recycling endosomes that regulates endocytic recycling of receptor proteins, and LIN-12/Notch whose downregulation, but not internalization, in primary vulval precursor cells requires ALX-1; alx-1 interacts genetically with ego-2, which encodes the second C. elegans Bro1 domain-containing protein, in a manner that suggests ALX-1 and EGO-2 function both agonistically and antagostically to regulate specific developmental processes; an ALX-1::GFP fusion protein is expressed ubiquitously at high levels and localizes to two types of endocytic organelles: the HGRS-1-positive multivesicular endosome and the RME-1-positive recycling endosome.