Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name
alg-2  
Sequence Name
T07D3.7  
WB ID
WBGene00000106  
Description
alg-2 encodes a PAZ and PIWI-domain containing protein that is a member of the highly conserved eukaryotic RDE-1/AGO1/PIWI family of proteins that regulate posttranscriptional gene silencing (PTGS); ALG-2 functions with ALG-1 to control specific developmental timing events by positively regulating expression of small temporal RNAs (stRNAs) encoded by lin-4 and let-7; ALG-2 and ALG-1 are also required for RNAi in the germ line, although they are not required for RNAi in the soma; ALG-2 is expressed in nearly all cells from embryogenesis through adulthood and localizes to the cytoplasm.  


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