Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

Y41E3.16  

Sequence Name

Y41E3.16  

WB ID

WBGene00012774  

Description

Y41E3.16 encodes an unfamiliar protein with an N-terminal DNA-binding SAP domain and extensive regions of low-complexity sequence, which has no clear homologs outside of nematodes; the Y41E3.16 transcription unit has a natural nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that Y41E3.16 is a natural substrate for SMG-mediated nonsense suppresssion; since several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-8, rpl-10a, rpl-12) have protein products that are involved in translation, Y41E3.16 protein may function in translation as well.