Clickable version of the Functional Landscape of the ParanomeAbout this figureA visualisation of the preferentially retained duplicated genes according to their functional classes
How it was made
For those genomes for which a COG classification is available at NCBI),
the classification was transferred to our database of the bacterial proteome on a gene by gene basis. Further, the
proteome of each genome was subdivided in 2 groups, i.e. paralogous genes and singel copy genes (based on the
constructed gene families), and per group a distribution over the different
functional categories was calculated in terms of percentage. The Functional Landscape is than defined as the
difference between the functional distribution of the paranome and the functional distribution of the single copy
genes. As a result one can deduce the functional classes that have relatively more (yellow to red),
or less (gradient of blue) paralogs compared to single copy genes. The genomes were listed according to the
ordering of organisms in the phylogenetic tree of Fig. 1 (in the manuscript), whereas the functional classes have
been ordered according to relative contribution. |
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