Towards system level modeling of functional modules and regulatory pathways using genome-scale data.

Understanding complex biological processes such as developmentand pathology of multicellular organisms at asystem level requires the study of dynamic networks of interactingmolecules. High-throughput methods have generatedlarge-scale, static networks of physical interactionswhich may occur or not depending on spatial, temporalor context-specific variation, while genome-wide microarraydatasets measure the functional state of a cell preciselyunder such varying conditions. Here we presentrecent results towards integrative, system level modelingof functional modules and regulatory pathways using diversegenome-scale data.

Michoel, T., Joshi, A., Bonnet, E., Vermeirssen, V., Van de Peer, Y. (2010) Towards system level modeling of functional modules and regulatory pathways using genome-scale data. Proceedings of the Seventh International Workshop on Computational Systems Biology (WCSB 2010) 71-74. Luxembourg, Luxembourg.

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