Some membrane bound proteins possess a pair of repeats each spanning two transmembrane helices connected by a loop [1]. The PQ motif found on loop 2 is critical for the localisation of cystinosin to lysosomes [2]. However, the PQ motif appears not to be a general lysosome-targeting motif. It is thought to possess a more general function; most probably this involves a glutamine residue [3].

1. Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution. Genome Res. 11, 1996-2008
2. The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motif. J. Biol. Chem. 276, 13314-21

Some membrane bound proteins possess a pair of repeats each spanning two transmembrane helices co
Show more...

Download genes (select columns to include)