Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups [1].

The amino-terminal region of the ACP proteins is well defined and consists of alpha four helices arranged in a right-handedbundle held together by interhelical hydrophobic interactions. The Asp-Ser-Leu (DSL) motif is conserved in all of the ACP sequences, and the 4'-PP prosthetic group is covalently linkedvia a phosphodiester bond to the serine residue. The DSL sequence is present at the amino terminus of helix II, a domain of the protein referred to as the recognition helix and which is responsible for theinteraction of ACPs with the enzymes of type II fatty acid synthesis [2].

1. Studies on the mechanism of fatty acid synthesis. XIV. The prosthetic group of acyl carrier protein and the mode of its attachment to the protein. J. Biol. Chem. 240, 4727-33
2. The solution structure of acyl carrier protein from Mycobacterium tuberculosis. J. Biol. Chem. 277, 15874-80

Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins
Show more...

Download genes (select columns to include)