This family of proteins is required for the insertion of integral membrane proteins into cellular membranes. Many of these integral membrane proteins are associated with respiratory chain complexes, for example a large number of members of this family play an essential role in the activity and assembly of cytochrome c oxidase.

Stage III sporulation protein J (SP3J) is a probable lipoprotein, rich in basic and hydrophobic amino acids. Mutations in the protein abolish the transcription of prespore-specific genes transcribed by the sigma G form of RNA polymerase [1]. SP3J could be involved in a signal transduction pathway coupling gene expression in the prespore to events in the mother cell, or it may be necessary for essential metabolic interactions between the two cells [2]. The protein shows a high degree of similarity to Bacillus subtilis YQJG, to yeast OXA1 and also to bacterial 60 kDa inner-membrane proteins [2, 3, 4, 5].

1. Structure and function of the spoIIIJ gene of Bacillus subtilis: a vegetatively expressed gene that is essential for sigma G activity at an intermediate stage of sporulation. J. Gen. Microbiol. 138, 2609-18
2. DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication. Genomics 16, 551-61
3. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269, 496-512
4. Genes and their organization in the replication origin region of the bacterial chromosome. Mol. Microbiol. 6, 629-34
5. Cloning and characterization of an autonomous replication sequence from Coxiella burnetii. J. Bacteriol. 176, 5233-43

This family of proteins is required for the insertion of integral membrane proteins into cellula
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