This group of serine peptidases belong to MEROPS peptidase family S10 (clan SC). The type example is carboxypeptidase Y from Saccharomyces cerevisiae (Baker's yeast) [1].

All known carboxypeptidases are either metallo carboxypeptidases or serine carboxypeptidases (3.4.16.5 and 3.4.16.6). The catalytic activity of the serine carboxypeptidases, like that of the trypsin family serine proteases, is provided by a charge relay system involving an aspartic acid residue hydrogen-bonded to a histidine, which is itself hydrogen-bonded to a serine [2]. The sequences surrounding the active site serine and histidine residues are highly conserved in all the serine carboxypeptidases.

1. Families of serine peptidases. Meth. Enzymol. 244, 19-61
2. Structure of wheat serine carboxypeptidase II at 3.5-A resolution. A new class of serine proteinase. J. Biol. Chem. 265, 6528-31

This group of serine peptidases belong to MEROPS peptidase family S10 (clan SC). The type example
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