Gene: AT5G60410 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
Chr5 : 24295226-24300671 : positive


Gene family
(92 genes in 28 species)
specific family


DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein
Curated Summary
Encodes a plant small ubiquitin-like modifier (SUMO) E3 ligase that is a focal controller of Pi starvation-dependent responses. Also required for SA and PAD4-mediated R gene signalling, which in turn confers innate immunity in Arabidopsis. Also involved in the regulation of plant growth, drought responses and freezing tolerance. This latter effect is most likely due to SIZ1 dependent ABI5 sumoylation. Regulates leaf cell division and expansion through salicylic acid accumulation. signaling
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Type Value
NoteDNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein







Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0016049 IMP, IEA, UniProtcell growth1
GO:0016925 IDA, IEA, UniProtprotein sumoylation1 2
GO:0031668 IEAInterProcellular response to extracellular stimulus
GO:0010286 IMPUniProtheat acclimation1
GO:0009864 IMPGene Ontologyinduced systemic resistance, jasmonic acid mediated signaling pathway1
GO:0010113 IMPUniProtnegative regulation of systemic acquired resistance1
GO:0050826 IMPUniProtresponse to freezing1
GO:0009414 IMPUniProtresponse to water deprivation1
GO:0040008 IMPUniProtregulation of growth1
GO:0048589 IMPUniProtdevelopmental growth1
GO:2000070 IMPUniProtregulation of response to water deprivation1
GO:0009910 IMPUniProtnegative regulation of flower development1
GO:0009787 IMPUniProtregulation of abscisic acid-activated signaling pathway1
GO:0010337 IMPUniProtregulation of salicylic acid metabolic process1
GO:0051301 IMPUniProtcell division1
GO:0010247 IDAUniProtdetection of phosphate ion1
GO:0016036 IMPUniProtcellular response to phosphate starvation1
GO:0090352 IMPUniProtregulation of nitrate assimilation1
GO:0009553 IMPUniProtembryo sac development1
GO:0010183 IMPUniProtpollen tube guidance1
GO:0048481 IMPUniProtplant ovule development1
GO:0006952 IEAUniProtdefense response

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0019789 IDA, IMP, IEA, UniProtSUMO transferase activity1 2
GO:0008270 IEAUniProtzinc ion binding1
GO:0003677 ISSGene OntologyDNA binding1
GO:0016874 IEAUniProtligase activity1
GO:0005515 IPIGene Ontologyprotein binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634 IDA, ISM, IEA, UniProtnucleus1 2
GO:0016607 IEAUniProtnuclear speck1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR013083Zinc finger, RING/FYVE/PHD-type
IPR003034SAP domain
IPR031141E3 SUMO-protein ligase SIZ1, plant
IPR004181Zinc finger, MIZ-type
IPR019786Zinc finger, PHD-type, conserved site
IPR001965Zinc finger, PHD-type
IPR011011Zinc finger, FYVE/PHD-type

Mapman id Description homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities.E3 ligase (SIZ1)
No SignalP domains detected for this gene.