Gene: AT5G58230 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT5G58230
Transcript Identifier
AT5G58230.1
Gene Type
Coding gene
Location
Chr5 : 23556112-23557994 : positive

Family

Gene family
HOM04M001536
(97 genes in 29 species)
specific family
Subfamily
ORTHO04M001632
(90 genes in 29 species)
specific family

Descriptions

Description
Transducin/WD40 repeat-like superfamily protein
Curated Summary
Encodes a WD-40 repeat containing protein that functions in chromatin assembly as part of the CAF1 and FIE complex. Mutants exhibit parthenogenetic development that includes proliferation of unfertilized endosperm and embryos. In heterozygous plants 50% of embryos abort. Of the aborted embryos the early aborted class are homozygous and the later aborting lass are heterozygotes in which the defective allele is maternally transmitted. Other phenotypes include defects in ovule morphogenesis and organ initiation,as well as increased levels of heterochromatic DNA. MSI1 is needed for the transition to flowering. In Arabidopsis, the three CAF-1 subunits are encoded by FAS1, FAS2 and, most likely, MSI1, respectively. Mutations in FAS1 or FAS2 lead to increased frequency of homologous recombination and T-DNA integration in Arabidopsis. In the ovule, the MSI1 transcripts are accumulated at their highest level before fertilization and gradually decrease after fertilization. MSI is biallelically expressed, the paternall allele is expressed in the endosperm and embryo and is not imprinted. MSI1 forms a complex with RBR1 that is required for activation of the imprinted genes FIS2 and FWA. This activation is mediated by MSI1/RBR1 mediated repression of MET1.
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Identifiers

Type Value
AliasATMSI1,ARABIDOPSIS MULTICOPY SUPRESSOR OF IRA1,MEE70,MATERNAL EFFECT EMBRYO ARREST 70
full_nameMULTICOPY SUPRESSOR OF IRA1
symbolMSI1
tidAT5G58230.1
UniProtO22467

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006260 IEAUniProtDNA replication1
GO:0006351 IEAUniProttranscription, DNA-templated1
GO:0006355 IEAUniProtregulation of transcription, DNA-templated1
GO:0009908 IEAUniProtflower development1
GO:0016569 IEAUniProtcovalent chromatin modification1
GO:0007275 IMPUniProtmulticellular organism development1
GO:0070828 IMPUniProtheterochromatin organization1
GO:0009793 IMPUniProtembryo development ending in seed dormancy1
GO:0031507 IMPUniProtheterochromatin assembly1
GO:0009909 IMPUniProtregulation of flower development1
GO:0008283 IMPUniProtcell proliferation1
GO:0010026 IMPUniProttrichome differentiation1
GO:0048366 IMPUniProtleaf development1
GO:0010214 IMPUniProtseed coat development1
GO:0048316 IMPUniProtseed development1
GO:0009555 IMP, IGIUniProtpollen development1 2
GO:0045787 IGIUniProtpositive regulation of cell cycle1
GO:0006349 IPIUniProtregulation of gene expression by genetic imprinting1
GO:2000653 IDAUniProtregulation of genetic imprinting1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005515 IPI, IEAGene Ontologyprotein binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634 TAS, ISMUniProtnucleus1 2
GO:0043234 IPIUniProtprotein complex1
GO:0009507 IDAUniProtchloroplast1
GO:0080008 ISSUniProtCul4-RING E3 ubiquitin ligase complex1
GO:0005677 IDAUniProtchromatin silencing complex1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR015943WD40/YVTN repeat-like-containing domain
IPR022052Histone-binding protein RBBP4, N-terminal
IPR001680WD40 repeat
IPR020472G-protein beta WD-40 repeat
IPR019775WD40 repeat, conserved site
IPR017986WD40-repeat-containing domain

Mapman id Description
12.2.1.3.Chromatin organisation.histone chaperone activities.CAF1 histone chaperone complex.component CAF1c/MSI
12.3.3.1.1.1.Chromatin organisation.histone modifications.histone lysine methylation.PRC2 histone methylation complex.VRN/FIS/EMF core subcomplexes.component MSI1
No SignalP domains detected for this gene.