Gene: AT5G41360 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT5G41360
Transcript Identifier
AT5G41360.1
Gene Type
Coding gene
Location
Chr5 : 16544574-16549121 : positive

Family

Gene family
HOM04M004021
(44 genes in 27 species)
specific family
Subfamily
ORTHO04M006482
(37 genes in 27 species)
specific family
Duplication type
Tandem duplicate

Descriptions

Description
homolog of Xeroderma pigmentosum complementation group B 2
Curated Summary
Encodes XPB2, a DNA repair protein and transcription factor. Arabidopsis thaliana has duplicated XPB gene (AtXPB1 and AtXPB2, with high similarity to each other). XPB proteins are involved in both DNA repair and transcription, they are component of the transcription factor IIH (TFIIH) and are responsible for DNA helicase activity during nucleotide (nt) excision repair (NER). Complementation assays in yeast rad25 mutant strains suggest the involvement of AtXPB2 in DNA repair. Although both genes are expressed in a constitutive manner during the plant life cycle, Northern blot analyses suggest that light modulates the expression level of both XPB copies.
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Identifiers

Type Value
AliasATXPB2,ARABIDOPSIS HOMOLOG OF XERODERMA PIGMENTOSUM COMPLEMENTATION GROUP B 2
symbolXPB2
tidAT5G41360.1
UniProtQ9FUG4

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006289 IEAUniProtnucleotide-excision repair1
GO:0006367 IEAUniProttranscription initiation from RNA polymerase II promoter1
GO:0006355 IEAUniProtregulation of transcription, DNA-templated1
GO:0010224 IEPUniProtresponse to UV-B1
GO:0009636 IEAPLAZA Integrative Orthologyresponse to toxic substanceAT5G41370
GO:0009411 IEAPLAZA Integrative Orthologyresponse to UVAT5G41370

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003677 IEAUniProtDNA binding1
GO:0005524 IEAUniProtATP binding1
GO:0016787 IEAInterProhydrolase activity
GO:0004003 IEAUniProtATP-dependent DNA helicase activity1
GO:0008026 ISSGene OntologyATP-dependent helicase activity1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634 IEA, ISM, UniProtnucleus1 2
GO:0005737 IEAPLAZA Integrative OrthologycytoplasmAT5G41370

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR032830Helicase XPB/Ssl2, N-terminal domain
IPR032438ERCC3/RAD25/XPB helicase, C-terminal domain
IPR006935Helicase/UvrB, N-terminal
IPR001650Helicase, C-terminal
IPR014001Helicase superfamily 1/2, ATP-binding domain
IPR027417P-loop containing nucleoside triphosphate hydrolase
IPR001161Helicase XPB/Ssl2

Mapman id Description
14.6.3.2.3.DNA damage response.nucleotide excision repair (NER).multi-functional TFIIh complex.core module.subunit SSL2/XPB
15.3.5.6.1.3.RNA biosynthesis.RNA polymerase II-dependent transcription.transcription initiation.TFIIh basal transcription factor complex.core module.component SSL2/XPB
No SignalP domains detected for this gene.