Gene: AT5G11390 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT5G11390
Transcript Identifier
AT5G11390.1
Gene Type
Coding gene
Location
Chr5 : 3633971-3636418 : positive

Family

Gene family
HOM04M000144
(613 genes in 29 species)
specific family

Descriptions

Description
WPP domain-interacting protein 1
Curated Summary
Encodes one of the WPP domain-interacting proteins (WIT1/AT5G11390, WIT2/AT1G68910) required for RanGAP nuclear envelope association in root tip cells. Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. The cytoplasmic Ran GTPase activating protein RanGAP is critical to establish a functional RanGTP/RanGDP gradient across the nuclear envelope and is associated with the outer surface of the nuclear envelope in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association with the root tip nuclear envelope requires a family of likely plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). WIT1 and WIT2 have been identified as a second family of CC-TMD proteins, structurally similar, yet clearly distinct from the WIP family, that is required for RanGAP nuclear envelop association in root tip cells.
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Identifiers

Type Value
symbolWIT1
tidAT5G11390.1
UniProtQ8L7E5

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0008150 NDGene Ontologybiological_process1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005515 IPIGene Ontologyprotein binding1
GO:0046983 IEAPLAZA Homology (enrichment)protein dimerization activity

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0016021 IEAUniProtintegral component of membrane1
GO:0031965 IEAUniProtnuclear membrane1
GO:0005635 IDAUniProtnuclear envelope1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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No InterPro domains detected for this gene.
Mapman id Description
20.4.2.2.Cytoskeleton organisation.nuclear dynamics.nuclear movement.myosin-SUN-WIP adaptor (WIT)
No SignalP domains detected for this gene.