PLAZA 4.0 Monocots gene overview : AT4G33240

Gene: AT4G33240 (Arabidopsis thaliana)

Curated Summary: Encodes a protein that is predicted to act as a 1-phosphatidylinositol-3-phosphate (PtdIns3P) 5-kinase based on its homology to Fab1 from yeast. It contains an FYVE domain required for binding to PtdIns3P-containing membranes in yeast, as well as a Cpn60_TCP1 homology domain plus a kinase domain. fab1a/fab1b pollen grains not viable and have defective vacuolar organization. FAB1A and FAB1B complement the enlarged vacuolar phenotype of the fission yeast ste12delta mutant.

Type	Value
full_name	FORMS APLOID AND BINUCLEATE CELLS 1A
symbol	FAB1A
tid	AT4G33240.1
UniProt	Q0WUR5

GO term	Evidence(s)	Provider	Description	Source
GO:0046488	IEA	InterPro	phosphatidylinositol metabolic process
GO:0006458	IBA	Gene Ontology	'de novo' protein folding	1
GO:0042147	IBA	UniProt	retrograde transport, endosome to Golgi	1
GO:0061077	IBA	Gene Ontology	chaperone-mediated protein folding	1
GO:0007033	IGI	UniProt	vacuole organization	1
GO:0009555	IGI	Gene Ontology	pollen development	1
GO:0010256	IGI	UniProt	endomembrane system organization	1

GO term	Evidence(s)	Provider	Description	Source
GO:0046872	IEA	UniProt	metal ion binding	1
GO:0016307	IEA	UniProt	phosphatidylinositol phosphate kinase activity	1
GO:0005524	IEA	UniProt	ATP binding	1
GO:0008270	ISS	Gene Ontology	zinc ion binding	1
GO:0016308	ISS	Gene Ontology	1-phosphatidylinositol-4-phosphate 5-kinase activity	1
GO:0044183	IBA	Gene Ontology	protein binding involved in protein folding	1
GO:0051082	IBA	Gene Ontology	unfolded protein binding	1
GO:0000285	IGI, ISS,	UniProt	1-phosphatidylinositol-3-phosphate 5-kinase activity	1 2

GO term	Evidence(s)	Provider	Description	Source
GO:0005634	ISM	Gene Ontology	nucleus	1
GO:0005737	ISM	Gene Ontology	cytoplasm	1
GO:0010008	IBA	UniProt	endosome membrane	1
GO:0005768	IDA	UniProt	endosome	1
GO:0005829	IEA	UniProt	cytosol

Experimental Evidence

Electronic Evidence

Computational Reviewed Evidence

InterPro	Description
IPR027409	GroEL-like apical domain
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR027483	Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
IPR027484	Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
IPR000306	FYVE zinc finger
IPR002498	Phosphatidylinositol-4-phosphate 5-kinase, core
IPR002423	Chaperonin Cpn60/TCP-1 family
IPR017455	Zinc finger, FYVE-related
IPR011011	Zinc finger, FYVE/PHD-type

Mapman id	Description
27.5.1.2	.Multi-process regulation.phosphoinositide lipid regulatory system.phosphatidylinositol 3-phosphate.phosphatidylinositol 3-phosphate 5-kinase (FAB1)

No SignalP domains detected for this gene.