Gene: AT4G33240 (Arabidopsis thaliana)

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Gene Identifier
AT4G33240
Transcript Identifier
AT4G33240.1
Gene Type
Coding gene
Location
Chr4 : 16029504-16037278 : negative

Family

Gene family
HOM04M000593
(209 genes in 29 species)
specific family

Descriptions

Description
1-phosphatidylinositol-3-phosphate 5-kinase FAB1A
Curated Summary
Encodes a protein that is predicted to act as a 1-phosphatidylinositol-3-phosphate (PtdIns3P) 5-kinase based on its homology to Fab1 from yeast. It contains an FYVE domain required for binding to PtdIns3P-containing membranes in yeast, as well as a Cpn60_TCP1 homology domain plus a kinase domain. fab1a/fab1b pollen grains not viable and have defective vacuolar organization. FAB1A and FAB1B complement the enlarged vacuolar phenotype of the fission yeast ste12delta mutant.
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Identifiers

Type Value
full_nameFORMS APLOID AND BINUCLEATE CELLS 1A
symbolFAB1A
tidAT4G33240.1
UniProtQ0WUR5

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0046488 IEAInterProphosphatidylinositol metabolic process
GO:0006458 IBAGene Ontology'de novo' protein folding1
GO:0042147 IBAUniProtretrograde transport, endosome to Golgi1
GO:0061077 IBAGene Ontologychaperone-mediated protein folding1
GO:0007033 IGIUniProtvacuole organization1
GO:0009555 IGIGene Ontologypollen development1
GO:0010256 IGIUniProtendomembrane system organization1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0046872 IEAUniProtmetal ion binding1
GO:0016307 IEAUniProtphosphatidylinositol phosphate kinase activity1
GO:0005524 IEAUniProtATP binding1
GO:0008270 ISSGene Ontologyzinc ion binding1
GO:0016308 ISSGene Ontology1-phosphatidylinositol-4-phosphate 5-kinase activity1
GO:0044183 IBAGene Ontologyprotein binding involved in protein folding1
GO:0051082 IBAGene Ontologyunfolded protein binding1
GO:0000285 IGI, ISS, UniProt1-phosphatidylinositol-3-phosphate 5-kinase activity1 2

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634 ISMGene Ontologynucleus1
GO:0005737 ISMGene Ontologycytoplasm1
GO:0010008 IBAUniProtendosome membrane1
GO:0005768 IDAUniProtendosome1
GO:0005829 IEAUniProtcytosol

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR027409GroEL-like apical domain
IPR013083Zinc finger, RING/FYVE/PHD-type
IPR027483Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
IPR027484Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
IPR000306FYVE zinc finger
IPR002498Phosphatidylinositol-4-phosphate 5-kinase, core
IPR002423Chaperonin Cpn60/TCP-1 family
IPR017455Zinc finger, FYVE-related
IPR011011Zinc finger, FYVE/PHD-type

Mapman id Description
27.5.1.2.Multi-process regulation.phosphoinositide lipid regulatory system.phosphatidylinositol 3-phosphate.phosphatidylinositol 3-phosphate 5-kinase (FAB1)
No SignalP domains detected for this gene.