Gene: AT4G15900 (Arabidopsis thaliana)

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Gene Identifier
AT4G15900
Transcript Identifier
AT4G15900.1
Gene Type
Coding gene
Location
Chr4 : 9023775-9027443 : positive

Family

Gene family
HOM04M004088
(44 genes in 29 species)
specific family
Duplication type
Block duplicate

Descriptions

Description
pleiotropic regulatory locus 1
Curated Summary
Mutations confer hypersensitivity to glucose and sucrose and augments sensitivity to cytokinin, ethylene, ABA and auxin. Encodes a nuclear WD40 protein that is imported into the nucleus. Essential for plant innate immunity. Interacts with MOS4 and AtCDC5. It is also predicted to have two DWD motifs. It can bind to DDB1a in Y2H assays, and DDB1b in co-IP assays, and may be involved in the formation of a CUL4-based E3 ubiquitin ligase, and may affect the stability of AKIN10.
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Identifiers

Type Value
symbolPRL1
tidAT4G15900.1
UniProtQ42384

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0000398 IBAUniProtmRNA splicing, via spliceosome1
GO:0016567 IEAUniProtprotein ubiquitination1
GO:0045087 IEAUniProtinnate immune response1
GO:0045892 IMPUniProtnegative regulation of transcription, DNA-templated1
GO:0009870 IMPUniProtdefense response signaling pathway, resistance gene-dependent1
GO:0010204 IMPUniProtdefense response signaling pathway, resistance gene-independent1
GO:0042742 IMPUniProtdefense response to bacterium1
GO:0050832 IMPUniProtdefense response to fungus1
GO:0006508 IMPUniProtproteolysis1
GO:0009755 IMPUniProthormone-mediated signaling pathway1
GO:0010154 IMPUniProtfruit development1
GO:0010182 IMPUniProtsugar mediated signaling pathway1
GO:0048364 IMPUniProtroot development1
GO:0048366 IMPUniProtleaf development1
GO:0048825 IMPUniProtcotyledon development1
GO:0009749 IMPUniProtresponse to glucose1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005515 IPI, IEAGene Ontologyprotein binding1
GO:0000166 ISSGene Ontologynucleotide binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0000974 IBAUniProtPrp19 complex1
GO:0005634 IDA, ISM, UniProtnucleus1 2
GO:0005662 IBAGene OntologyDNA replication factor A complex1
GO:0071011 IBAUniProtprecatalytic spliceosome1
GO:0071013 IBAUniProtcatalytic step 2 spliceosome1
GO:0080008 IPIUniProtCul4-RING E3 ubiquitin ligase complex1

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR015943WD40/YVTN repeat-like-containing domain
IPR001680WD40 repeat
IPR020472G-protein beta WD-40 repeat
IPR019775WD40 repeat, conserved site
IPR017986WD40-repeat-containing domain

Mapman id Description
16.4.5.1.3.RNA processing.pre-mRNA splicing.spliceosome-associated non-snRNP MOS4-associated complex (MAC).core components.component PRL1/MAC2
No SignalP domains detected for this gene.