Gene: AT4G03560 (Arabidopsis thaliana)

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Gene Identifier
AT4G03560
Transcript Identifier
AT4G03560.1
Gene Type
Coding gene
Location
Chr4 : 1580253-1585691 : positive

Family

Gene family
HOM04M004356
(42 genes in 25 species)
specific family

Descriptions

Description
two-pore channel 1
Curated Summary
Encodes a depolarization-activated Ca(2 ) channel. Anti-sense experiments with this gene as well as Sucrose-H( ) symporters and complementation of yeast sucrose uptake mutant cch1 suggest that this protein mediates a voltage-activated Ca(2 )influx. Mutants lack detectable SV channel activity suggesting TPC1 is essential component of the SV channel. Patch clamp analysis of loss of function mutation indicates TPC1 does not affect Ca2 signaling in response to abiotic and biotic stress.
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Identifiers

Type Value
AliasATCCH1,CALCIUM CHANNEL 1,ATTPC1,two-pore channel 1,FOU2,FATTY ACID OXYGENATION UPREGULATED 2
full_nametwo-pore channel 1
symbolTPC1
tidAT4G03560.1
UniProtQ94KI8

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006811 IEAInterProion transport
GO:0055085 IEAInterProtransmembrane transport
GO:0034765 IEAGene Ontologyregulation of ion transmembrane transport1
GO:0070588 IEAGene Ontologycalcium ion transmembrane transport1
GO:0086010 IBAUniProtmembrane depolarization during action potential1
GO:0006816 IMP, IC, UniProtcalcium ion transport1 2
GO:0009845 IMPUniProtseed germination1
GO:0010119 IMPUniProtregulation of stomatal movement1
GO:0080141 IMPUniProtregulation of jasmonic acid biosynthetic process1
GO:0019722 IMPUniProtcalcium-mediated signaling1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005509 IEAUniProtcalcium ion binding1
GO:0005245 ISS, IGI, IEA, UniProtvoltage-gated calcium channel activity1 2
GO:0005216 IEAInterProion channel activity
GO:0005262 IGI, IMP, ISSGene Ontologycalcium channel activity1 2 3

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0016020 IEAInterPromembrane
GO:0016021 IEAUniProtintegral component of membrane1
GO:0005886 TASUniProtplasma membrane1
GO:0005773 IDAUniProtvacuole1
GO:0000325 IDAUniProtplant-type vacuole1
GO:0005774 IDAUniProtvacuolar membrane1
GO:0005794 IDAUniProtGolgi apparatus1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR002048EF-hand domain
IPR028801Two pore calcium channel protein 1
IPR005821Ion transport domain
IPR011992EF-hand domain pair

Mapman id Description
24.3.2.1.Solute transport.channels.VIC superfamily.voltage-gated calcium cation channel (TPC)
No SignalP domains detected for this gene.