Gene: AT3G54610 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
Chr3 : 20213593-20217375 : positive


Gene family
(38 genes in 28 species)
specific family


histone acetyltransferase of the GNAT family 1
Curated Summary
Encodes a histone acetyltransferase that is plays a role in the determination of the embryonic root-shoot axis. It is also required to regulate the floral meristem activity by modulating the extent of expression of WUS and AG. In other eukaryotes, this protein is recruited to specific promoters by DNA binding transcription factors and is thought to promote transcription by acetylating the N-terminal tail of histone H3. The enzyme has indeed been shown to catalyse primarily the acetylation of H3 histone with only traces of H4 and H2A/B being acetylated. Non-acetylated H3 peptide or an H3 peptide that had been previously acetylated on K9 both serve as excellent substrates for HAG1-catalyzed acetylation. However, prior acetylation of H3 lysine 14 blocks radioactive acetylation of the peptide by HAG1. HAG1 is specific for histone H3 lysine 14.
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Type Value
AliasBGT,BIG TOP,GCN5,general control non-repressible 5,HAC3,HAG01,HAT1,HISTONE ACETYLTRANSFERASE 1







Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006351 IEAUniProttranscription, DNA-templated1
GO:0045893 TASUniProtpositive regulation of transcription, DNA-templated1
GO:0009908 IMPUniProtflower development1
GO:0009416 IMPUniProtresponse to light stimulus1
GO:0010015 IMPUniProtroot morphogenesis1
GO:0016573 IDAUniProthistone acetylation1
GO:0010321 IMPUniProtregulation of vegetative phase change1 2
GO:0030154 IBAUniProtcell differentiation
GO:0010438 TASUniProtcellular response to sulfur starvation
GO:0050832 IMPUniProtdefense response to fungus
GO:0009682 IMPUniProtinduced systemic resistance
GO:0010439 IMPUniProtregulation of glucosinolate biosynthetic process
GO:0006357 IBAUniProtregulation of transcription from RNA polymerase II promoter
GO:0006355 IEPUniProtregulation of transcription, DNA-templated
GO:0009617 IMPUniProtresponse to bacterium
GO:0009739 IEPUniProtresponse to gibberellin
GO:0009625 IEPUniProtresponse to insect
GO:0009753 IEPUniProtresponse to jasmonic acid
GO:0009751 IEPUniProtresponse to salicylic acid

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005515 IPI, IEAGene Ontologyprotein binding1
GO:0008080 IEAInterProN-acetyltransferase activity
GO:0004402 IDA, ISS, UniProthistone acetyltransferase activity1 2
GO:0003677 IDAUniProtDNA binding1
GO:0010484 IDAUniProtH3 histone acetyltransferase activity1
GO:0016407 IDAUniProtacetyltransferase activity1 2
GO:0000981 IBAUniProtRNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0043565 IPIUniProtsequence-specific DNA binding
GO:0001135 IBAUniProttranscription factor activity, RNA polymerase II transcription factor recruiting
GO:0003700 ISSUniProttranscription factor activity, sequence-specific DNA binding
GO:0044212 IBAUniProttranscription regulatory region DNA binding

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634 IDA, ISM, UniProtnucleus1 2
GO:0000123 IPIUniProthistone acetyltransferase complex1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000182GNAT domain
IPR018359Bromodomain, conserved site
IPR016181Acyl-CoA N-acyltransferase

Mapman id Description biosynthesis.RNA polymerase II-dependent transcription.SAGA transcription co-activator complex.HAT histone acetyltransferase module.component GCN5/ADA4
No SignalP domains detected for this gene.