Gene: AT3G50630 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT3G50630
Transcript Identifier
AT3G50630.2
Gene Type
Coding gene
Location
Chr3 : 18800508-18801228 : positive

Family

Gene family
HOM04M113662
(orphan gene)
specific family

Descriptions

Description
KIP-related protein 2
Curated Summary
Kip-related protein (KRP) gene, encodes CDK (cyclin-dependent kinase) inhibitor (CKI), negative regulator of cell division. A member of seven KRP genes found in Arabidopsis thaliana. Differential expression patterns for distinct KRPs were revealed by in situ hybridization. Gene was isolated from a yeast two hybrid screen as an interacting protein of CDC2A. Recombinant protein has a strong kinase inhibitor activity in vitro. Transcript is expressed in all tissues examined but is differentially distributed from ICK1. Controls the onset of the endoreduplication cycle through inhibition of CDKA;1. The KRP2 protein abundance is regulated by proteolysis through CDKB1;1 phosphorylation.
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Identifiers

Type Value
AliasICK2
symbolKRP2
tidAT3G50630.2

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0007050 IEAUniProtcell cycle arrest1
GO:0045736 IDA, ISS, UniProtnegative regulation of cyclin-dependent protein serine/threonine kinase activity1 2
GO:0042023 IMPUniProtDNA endoreduplication1
GO:0009733 IEPUniProtresponse to auxin

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004861 IEA, IGI, ISS, UniProtcyclin-dependent protein serine/threonine kinase inhibitor activity1 2 3
GO:0005515 IPIGene Ontologyprotein binding1
GO:0019210 IDAUniProtkinase inhibitor activity1
GO:0005509 ISSUniProtcalcium ion binding

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634 IEA, ISM, UniProtnucleus1 2
GO:0005654 IEAUniProtnucleoplasm1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003175Cyclin-dependent kinase inhibitor

Mapman id Description
35.1not assigned.annotated
No SignalP domains detected for this gene.