Gene: AT3G48750 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
Chr3 : 18072238-18074296 : positive


Gene family
(1370 genes in 29 species)
specific family


cell division control 2
Curated Summary
A-type cyclin-dependent kinase. Together with its specific inhibitor, the Kip-related protein, KRP2 they regulate the mitosis-to-endocycle transition during leaf development. Dominant negative mutations abolish cell division. Loss of function phenotype has reduced fertility with failure to transmit via pollen. Pollen development is arrested at the second mitotic division. Expression is regulated by environmental and chemical signals. Part of the promoter is responsible for expression in trichomes. Functions as a positive regulator of cell proliferation during development of the male gametophyte, embryo and endosperm. Phosphorylation of threonine 161 is required for activation of its associated kinase.
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Type Value







Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006468 IEAInterProprotein phosphorylation
GO:0000226 IBAUniProtmicrotubule cytoskeleton organization1
GO:0006281 IBAUniProtDNA repair1
GO:0007346 IBAUniProtregulation of mitotic cell cycle1
GO:0010468 IBAUniProtregulation of gene expression1
GO:0016572 IBAUniProthistone phosphorylation1
GO:0030154 IBAGene Ontologycell differentiation1
GO:0044772 IBAUniProtmitotic cell cycle phase transition1
GO:0042023 IMPUniProtDNA endoreduplication1
GO:0009555 IMPUniProtpollen development1
GO:0008284 IMPUniProtpositive regulation of cell proliferation1
GO:0009793 IMPUniProtembryo development ending in seed dormancy1
GO:0040020 IMPUniProtregulation of meiotic nuclear division1
GO:0048229 IMPUniProtgametophyte development1
GO:0008356 IGIUniProtasymmetric cell division1
GO:0010235 IMPUniProtguard mother cell cytokinesis1 2
GO:0010444 IMPUniProtguard mother cell differentiation1 2
GO:0098725 IMPUniProtsymmetric cell division1 2
GO:1902806 IMPUniProtregulation of cell cycle G1/S phase transition1 2
GO:0000911 IMPUniProtcytokinesis by cell plate formation1
GO:0009409 IEPUniProtresponse to cold1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004672 IDA, IEA, UniProtprotein kinase activity1
GO:0005524 IEAUniProtATP binding1
GO:0004693 ISS, IBA, UniProtcyclin-dependent protein serine/threonine kinase activity1 2
GO:0008353 IEAUniProtRNA polymerase II carboxy-terminal domain kinase activity1
GO:0016301 IMP, ISS, UniProtkinase activity1 2
GO:0005515 IPIGene Ontologyprotein binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634 IDA, ISM, UniProtnucleus1 2
GO:0072686 IBAUniProtmitotic spindle1
GO:0005886 IDAUniProtplasma membrane1
GO:0005829 IDAUniProtcytosol1
GO:0005737 IDAUniProtcytoplasm1
GO:0009574 TASUniProtpreprophase band1
GO:0010005 IDAUniProtcortical microtubule, transverse to long axis1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR008271Serine/threonine-protein kinase, active site
IPR017441Protein kinase, ATP binding site
IPR011009Protein kinase-like domain

Mapman id Description cycle organisation.cell cycle control.cyclin-dependent regulation.cyclin-dependent protein kinase complex.catalytic component CDKA modification.phosphorylation.CMGC protein kinase superfamily.CDK protein kinase families.protein kinase (CDKA)
No SignalP domains detected for this gene.