Gene: AT3G25070 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT3G25070
Transcript Identifier
AT3G25070.1
Gene Type
Coding gene
Location
Chr3 : 9132458-9133747 : positive

Family

Gene family
HOM04M001899
(81 genes in 26 species)
specific family

Descriptions

Description
RPM1 interacting protein 4
Curated Summary
Encodes a member of the R protein complex and may represent a virulence target of type III pili effector proteins (virulence factors) from bacterial pathogens, which is 'guarded' by R protein complex (RPM1 and RPS2 proteins). RIN4 physically interacts with RPS2 and RPM1 in vivo. Bacterial avirulence (Avr) effectors AvrB, AvrRpm1, and AvrRpt2 induce a mobility shift in RIN4 and expression of AvrRpt2 induces rapid degradation of RIN4. RIN4 contains 2 sites for AvrRpt2 autocleavage, called RCS1 and RCS2. Overexpression of RIN4 inhibits multiple phenotypes associated with AvrRpt2 function and also inhibits PAMP-induced defense signaling. Attached to the plasma membrane at its carboxyl terminus. Cleaved by AvrRpt2 at two PxFGxW motifs, one releasing a large portion of RIN4 from the plasma membrane and both exposing amino-terminal residues that destabilized the carboxyl-terminal cleavage products by targeting them for N-end ubiquitylation and proteasomal degradation. Major virulence target of the TTSE HopF2Pto.
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Identifiers

Type Value
AliasAtRIN4
symbolRIN4
tidAT3G25070.1
UniProtQ8GYN5

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0009816 IMPUniProtdefense response to bacterium, incompatible interaction1
GO:0006468 IDAUniProtprotein phosphorylation1
GO:0034051 IMPUniProtnegative regulation of plant-type hypersensitive response1
GO:0009626 IMPUniProtplant-type hypersensitive response1
GO:0002237 IMPUniProtresponse to molecule of bacterial origin1
GO:0010204 IMPUniProtdefense response signaling pathway, resistance gene-independent1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005515 IPIGene Ontologyprotein binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634 ISMGene Ontologynucleus1
GO:0012505 IEAUniProtendomembrane system1
GO:0016020 IDAUniProtmembrane1
GO:0005886 IDA, TAS, UniProtplasma membrane1 2
GO:0019897 IDAUniProtextrinsic component of plasma membrane1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR008700RIN4, pathogenic type III effector avirulence factor Avr cleavage site

Mapman id Description
26.8.2.2.2.External stimuli response.pathogen.effector-triggered immunity (ETI) network.RIN4-RPM1 immune signalling.RPM1-interacting factor (RIN4)
No SignalP domains detected for this gene.