PLAZA 4.0 Monocots gene overview : AT3G25070

Gene: AT3G25070 (Arabidopsis thaliana)

Curated Summary: Encodes a member of the R protein complex and may represent a virulence target of type III pili effector proteins (virulence factors) from bacterial pathogens, which is 'guarded' by R protein complex (RPM1 and RPS2 proteins). RIN4 physically interacts with RPS2 and RPM1 in vivo. Bacterial avirulence (Avr) effectors AvrB, AvrRpm1, and AvrRpt2 induce a mobility shift in RIN4 and expression of AvrRpt2 induces rapid degradation of RIN4. RIN4 contains 2 sites for AvrRpt2 autocleavage, called RCS1 and RCS2. Overexpression of RIN4 inhibits multiple phenotypes associated with AvrRpt2 function and also inhibits PAMP-induced defense signaling. Attached to the plasma membrane at its carboxyl terminus. Cleaved by AvrRpt2 at two PxFGxW motifs, one releasing a large portion of RIN4 from the plasma membrane and both exposing amino-terminal residues that destabilized the carboxyl-terminal cleavage products by targeting them for N-end ubiquitylation and proteasomal degradation. Major virulence target of the TTSE HopF2Pto.

GO term	Evidence(s)	Provider	Description	Source
GO:0009816	IMP	UniProt	defense response to bacterium, incompatible interaction	1
GO:0006468	IDA	UniProt	protein phosphorylation	1
GO:0034051	IMP	UniProt	negative regulation of plant-type hypersensitive response	1
GO:0009626	IMP	UniProt	plant-type hypersensitive response	1
GO:0002237	IMP	UniProt	response to molecule of bacterial origin	1
GO:0010204	IMP	UniProt	defense response signaling pathway, resistance gene-independent	1

GO term	Evidence(s)	Provider	Description	Source
GO:0005515	IPI	Gene Ontology	protein binding	1

GO term	Evidence(s)	Provider	Description	Source
GO:0005634	ISM	Gene Ontology	nucleus	1
GO:0012505	IEA	UniProt	endomembrane system	1
GO:0016020	IDA	UniProt	membrane	1
GO:0005886	IDA, TAS,	UniProt	plasma membrane	1 2
GO:0019897	IDA	UniProt	extrinsic component of plasma membrane	1

Experimental Evidence

Electronic Evidence

Computational Reviewed Evidence

InterPro	Description
IPR008700	RIN4, pathogenic type III effector avirulence factor Avr cleavage site

Mapman id	Description
26.8.2.2.2	.External stimuli response.pathogen.effector-triggered immunity (ETI) network.RIN4-RPM1 immune signalling.RPM1-interacting factor (RIN4)

No SignalP domains detected for this gene.