Gene: AT3G22590 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT3G22590
Transcript Identifier
AT3G22590.1
Gene Type
Coding gene
Location
Chr3 : 8003999-8005452 : positive

Family

Gene family
HOM04M005096
(38 genes in 27 species)
specific family

Descriptions

Description
PLANT HOMOLOGOUS TO PARAFIBROMIN
Curated Summary
Encodes PLANT HOMOLOGOUS TO PARAFIBROMIN (PHP), a homolog of human Paf1 Complex (Paf1C) subunit Parafibromin. Human Parafibromin assists in mediating output from the Wnt signaling pathway, and dysfunction of the encoding gene HRPT2 conditions specific cancer-related disease phenotypes. PHP resides in a ~670-kDa protein complex in nuclear extracts, and physically interacts with other known Paf1C-related proteins in vivo. Loss of PHP specifically conditioned accelerated phase transition from vegetative growth to flowering and resulted in misregulation of a very limited subset of genes that included the flowering repressor FLOWERING LOCUS C (FLC).
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Identifiers

Type Value
AliasCDC73
symbolPHP
tidAT3G22590.1
UniProtQ9LJ87

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006368 IEAUniProttranscription elongation from RNA polymerase II promoter1
GO:0016570 IEAInterProhistone modification
GO:0009908 IEAUniProtflower development1
GO:0032968 IBAUniProtpositive regulation of transcription elongation from RNA polymerase II promoter1
GO:0034402 IBAUniProtrecruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex1
GO:0010228 IMPUniProtvegetative to reproductive phase transition of meristem1
GO:0009911 IMPUniProtpositive regulation of flower development1
GO:0051568 IMPUniProthistone H3-K4 methylation1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0000993 IBAUniProtRNA polymerase II core binding1
GO:0001076 IBAUniProttranscription factor activity, RNA polymerase II transcription factor binding1
GO:0005515 IPIGene Ontologyprotein binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0016593 IDA, IEA, UniProtCdc73/Paf1 complex1
GO:0005634 IDA, ISM, UniProtnucleus1 2
GO:0070860 ISSGene OntologyRNA polymerase I core factor complex1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR007852Cdc73/Parafibromin
IPR032041Paf1 complex subunit Cdc73, N-terminal domain
IPR031336Cell division control protein 73, C-terminal

Mapman id Description
15.3.6.1.5.RNA biosynthesis.RNA polymerase II-dependent transcription.transcription elongation.PAF1C transcription initiation and elongation complex.component CDC73/PHP
No SignalP domains detected for this gene.