Gene: AT3G13170 (Arabidopsis thaliana)

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Gene Identifier
AT3G13170
Transcript Identifier
AT3G13170.1
Gene Type
Coding gene
Location
Chr3 : 4231560-4234192 : negative

Family

Gene family
HOM04M001378
(107 genes in 29 species)
specific family
Subfamily
ORTHO04M007932
(32 genes in 23 species)
specific family

Descriptions

Description
Spo11/DNA topoisomerase VI, subunit A protein
Curated Summary
Encodes AtSPO11-1, one of the three Arabidopsis homologues of the archaeal DNA topoisomerase VIA subunit (topo VIA). Required for meiotic recombination. AtSPO11-1 and AtSPO11-2 have overlapping functions (i.e. both required for meiotic recombination) whereas AtSPO11-3 functions in DNA replication. AtSPO11-1 accumulates in foci in early G2. At 1 h post-S phase, no foci are observed, but by 3 h a majority (80%) of meiocytes at this time point contain >50 foci. However, by 5 h, AtSPO11-1 foci are no longer detectable. This suggests that the protein undergoes a rapid cycle of accumulation and disappearance in meiocytes over a period of between 1 and 5 h post-S phase.
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Identifiers

Type Value
NoteSpo11/DNA topoisomerase VI, subunit A protein
symbolATSPO11-1
tidAT3G13170.1
UniProtQ9M4A2

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0000737 IEAUniProtDNA catabolic process, endonucleolytic1
GO:0006259 ISS, IEAGene OntologyDNA metabolic process1
GO:0006265 ISSGene OntologyDNA topological change1
GO:0007129 IMPGene Ontologysynapsis1
GO:0007131 IMPGene Ontologyreciprocal meiotic recombination1
GO:0034090 IGIGene Ontologymaintenance of meiotic sister chromatid cohesion1
GO:0042138 IGIGene Ontologymeiotic DNA double-strand break formation1
GO:0000706 IGIGene Ontologymeiotic DNA double-strand break processing1
GO:0051026 IMPGene Ontologychiasma assembly1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003677 IEA, IDA, ISSUniProtDNA binding1 2
GO:0003824 IEAInterProcatalytic activity
GO:0005524 IEA, ISS, UniProtATP binding1 2
GO:0003918 IBA, ISSGene OntologyDNA topoisomerase type II (ATP-hydrolyzing) activity1 2
GO:0016889 IBAGene Ontologyendodeoxyribonuclease activity, producing 3'-phosphomonoesters1
GO:0046872 IEAGene Ontologymetal ion binding1
GO:0005515 IPIGene Ontologyprotein binding1 2
GO:0016853 IEAUniProtisomerase activity

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005694 IEAUniProtchromosome
GO:0000228 IBAGene Ontologynuclear chromosome1
GO:0005634 IDA, ISMGene Ontologynucleus1 2

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR034136Topoisomerase 6 subunit A/Spo11, TOPRIM domain
IPR011991Winged helix-turn-helix DNA-binding domain
IPR002815Spo11/DNA topoisomerase VI subunit A
IPR013049Spo11/DNA topoisomerase VI, subunit A, N-terminal
IPR013048Meiotic recombination, Spo11

Mapman id Description
13.3.6.2.1.1.Cell cycle organisation.mitosis and meiosis.meiotic recombination.meiotic double strand break initiation.meiotic topoisomerase-VI complex.component a/SPO11
No SignalP domains detected for this gene.