Gene: AT2G47460 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT2G47460
Transcript Identifier
AT2G47460.1
Gene Type
Coding gene
Location
Chr2 : 19476438-19479242 : positive

Family

Gene family
HOM04M000010
(3187 genes in 28 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

Description
myb domain protein 12
Curated Summary
MYB12 belongs to subgroup 7 of the R2R3-MYB family. It strongly activates the promoters of chalcone synthase (CHS), flavanone 3-hydroxylase (F3H), flavonol synthase (FLS) and - to a lesser extent - chalcone flavanone isomerase (CHI), but cannot activate the promoters of flavonoid-3'hydroxylase (F3'H) and dihydroflavonol 4-reductase (DF). The activation requires a functional MYB recognition element (MRE). Results from the myb12-1f allele indicate that an activation domain might be present in the C-terminus. Overexpression or knock-out plants do not show any obvious phenotype under greenhouse conditions. Young myb12-ko seedlings contain reduced amounts of flavonoids (quercetin and kaempferol), while seedlings as well as leaves of MYB12-OX plants displayed an increased flavonoid content. They did not show any significant difference in anthocyanin content. Expression of CHS and FLS shows a clear correlation to MYB12 expression levels. CHI and F3H show increased transcript levels in the MYB12-OX lines, but no differences in the knock-out. Even in the absence of functional MYB12, flavonol biosynthesis is not completely absent, suggesting functional redundancy. The redundant factors are MYB11 and MYB111 although MYB12 is primarily required for flavonol biosynthesis in roots. Mutations in MYB12 block both auxin and ethylene stimulation of flavonoid synthesis.
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Identifiers

Type Value
AliasATMYB12,MYB DOMAIN PROTEIN 12,PFG1,PRODUCTION OF FLAVONOL GLYCOSIDES 1
symbolMYB12
tidAT2G47460.1
UniProtO22264

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006351 IEAUniProttranscription, DNA-templated1
GO:0006357 IBAUniProtregulation of transcription from RNA polymerase II promoter1
GO:0030154 IBAUniProtcell differentiation1
GO:0009813 IMPUniProtflavonoid biosynthetic process1
GO:0045893 IDAUniProtpositive regulation of transcription, DNA-templated1
GO:0051555 IMPUniProtflavonol biosynthetic process1
GO:0009416 IEPUniProtresponse to light stimulus1 2
GO:0010224 IMP, IEP, UniProtresponse to UV-B1 2 3 4
GO:1900386 IMPUniProtpositive regulation of flavonol biosynthetic process1 2
GO:0009723 IEPUniProtresponse to ethylene1
GO:0009733 IEPUniProtresponse to auxin1
GO:0009651 IMPUniProtresponse to salt stress1 2
GO:0006355 ISSGene Ontologyregulation of transcription, DNA-templated1
GO:0048640 IEAPLAZA Integrative Orthologynegative regulation of developmental growthAT3G62610
GO:0008285 IEAPLAZA Integrative Orthologynegative regulation of cell proliferationAT3G62610

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003677 ISS, IEAGene OntologyDNA binding1
GO:0000981 IBAUniProtRNA polymerase II transcription factor activity, sequence-specific DNA binding1
GO:0001135 IBAUniProttranscription factor activity, RNA polymerase II transcription factor recruiting1
GO:0003700 ISSUniProttranscription factor activity, sequence-specific DNA binding1
GO:0043565 IBAUniProtsequence-specific DNA binding1
GO:0044212 IBAUniProttranscription regulatory region DNA binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634 IDA, ISM, UniProtnucleus1 2 3

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001005SANT/Myb domain
IPR017930Myb domain
IPR009057Homeobox domain-like

Mapman id Description
15.5.2.1.RNA biosynthesis.transcriptional regulation.MYB transcription factor superfamily.transcription factor (MYB)
No SignalP domains detected for this gene.