Gene: AT2G46280 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT2G46280
Transcript Identifier
AT2G46280.2
Gene Type
Coding gene
Location
Chr2 : 19003656-19005393 : negative

Family

Gene family
HOM04M003134
(54 genes in 29 species)
specific family
Subfamily
ORTHO04M004284
(47 genes in 29 species)
specific family
Duplication type
Tandem duplicate

Descriptions

Description
TGF-beta receptor interacting protein 1
Curated Summary
Encodes a homolog of mammalian TGF-beta receptor interacting protein. Co-immunoprecipitates with BRI1 and can be phosphorylated in vitro by BRI1 at specific sites (Thr-14, Thr-89, and either Thr-197 or Ser-198). May therefore be a cytoplasmic BRI1 substrate and involved in brassinosteroid regulated plant growth and development.The encoded protein has two DWD motifs. It can bind to DDB1a in Y2H assays, and DDB1b in co-IP assays, and may be involved in the formation of a CUL4-based E3 ubiquitin ligase
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Identifiers

Type Value
AliasTIF3I1,TRIP1
symbolTRIP-1
tidAT2G46280.2
UniProtQ38884

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006413 IEAGene Ontologytranslational initiation1
GO:0046686 IEPGene Ontologyresponse to cadmium ion1
GO:0009651 IEPGene Ontologyresponse to salt stress1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003743 IEAGene Ontologytranslation initiation factor activity1
GO:0005515 IPI, IEAGene Ontologyprotein binding1
GO:0000166 ISSGene Ontologynucleotide binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005737 ISM, IEAGene Ontologycytoplasm1
GO:0005852 IEAGene Ontologyeukaryotic translation initiation factor 3 complex1
GO:0080008 IPIGene OntologyCul4-RING E3 ubiquitin ligase complex1
GO:0005829 IDAGene Ontologycytosol1
GO:0009506 IEAPLAZA Integrative OrthologyplasmodesmaAT2G46290

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR027525Eukaryotic translation initiation factor 3 subunit I
IPR001680WD40 repeat
IPR020472G-protein beta WD-40 repeat
IPR019775WD40 repeat, conserved site
IPR017986WD40-repeat-containing domain

Mapman id Description
17.4.1.3.9.Protein biosynthesis.translation initiation.Pre-Initiation Complex (PIC) module.eIF3 mRNA-to-PIC binding complex.component eIF3i
No SignalP domains detected for this gene.