Gene: AT2G36490 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT2G36490
Transcript Identifier
AT2G36490.1
Gene Type
Coding gene
Location
Chr2 : 15308259-15314272 : negative

Family

Gene family
HOM04M000985
(140 genes in 29 species)
specific family

Descriptions

Description
demeter-like 1
Curated Summary
A repressor of transcriptional gene silencing. Functions by demethylating the target promoter DNA. Interacts physically with RPA2/ROR1. In the ros1 mutants, an increase in methylation is observed in a number of gene promoters. Among the loci affected by ros1, a few (RD29A and At1g76930) are affected in cytosine methylation in all sequence contexts (CpG, CpNpG or CpNpN), although many others are affected primarily in non-CpG contexts.
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Identifiers

Type Value
AliasAtROS1,ROS1,REPRESSOR OF SILENCING1
symbolDML1
tidAT2G36490.1
UniProtQ9SJQ6

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006284 IEAUniProtbase-excision repair1
GO:0006281 IMP, IEA, UniProtDNA repair1
GO:0006351 IEAUniProttranscription, DNA-templated1
GO:0006342 IMPUniProtchromatin silencing1
GO:0006306 IDAUniProtDNA methylation1
GO:0031936 IMPUniProtnegative regulation of chromatin silencing1
GO:0080111 IMPUniProtDNA demethylation1
GO:0050832 IMPUniProtdefense response to fungus1 2

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0051539 IEAUniProt4 iron, 4 sulfur cluster binding1
GO:0003824 IEAInterProcatalytic activity
GO:0003677 IEAUniProtDNA binding1
GO:0046872 IEAUniProtmetal ion binding1
GO:0003906 IDA, ISS, UniProtDNA-(apurinic or apyrimidinic site) lyase activity1 2
GO:0019104 IDA, ISS, TAS, UniProtDNA N-glycosylase activity1 2 3
GO:0005515 IPIGene Ontologyprotein binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634 IDA, ISM, UniProtnucleus1 2
GO:0005730 IEAUniProtnucleolus1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003265HhH-GPD domain
IPR023170Helix-turn-helix, base-excision DNA repair, C-terminal
IPR028924Permuted single zf-CXXC unit
IPR028925Demeter, RRM-fold domain
IPR003651Endonuclease III-like, iron-sulphur cluster loop motif
IPR011257DNA glycosylase

Mapman id Description
12.5.3.1.Chromatin organisation.DNA methylation.ROS1-mediated DNA demethylation.methylcytosine-specific DNA glycosylase (ROS1)
14.5.4.DNA damage response.base excision repair (BER).bifunctional DNA glycosylase/lyase (ROS1)
No SignalP domains detected for this gene.