Gene: AT1G75950 (Arabidopsis thaliana)

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Gene Identifier
AT1G75950
Transcript Identifier
AT1G75950.1
Gene Type
Coding gene
Location
Chr1 : 28516715-28517454 : positive

Family

Gene family
HOM04M000290
(360 genes in 29 species)
specific family
Subfamily
ORTHO04M000184
(347 genes in 29 species)
specific family
Duplication type
Block duplicate

Descriptions

Description
S phase kinase-associated protein 1
Curated Summary
SKP1 is core component of the SCF family of E3 ubiquitin ligases and serves to tether the rest of the complex to an F-box protein, which provides specificity in binding to ubiquitin ligase substrate proteins. Predominately expressed from leptotene to pachytene. Negatively regulates recombination. Interacts with P0, a silencing suppressor protein encoded by poleroviruses by means of a conserved minimal F-box motif.
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Identifiers

Type Value
AliasASK1,ARABIDOPSIS SKP1 HOMOLOGUE 1,ATSKP1,SKP1A,UIP1,UFO INTERACTING PROTEIN 1
symbolSKP1
tidAT1G75950.1
UniProtQ39255

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006511 IEA, TAS, UniProtubiquitin-dependent protein catabolic process1 2
GO:0007059 IEAUniProtchromosome segregation1
GO:0007275 IEAUniProtmulticellular organism development1
GO:0009734 IEAUniProtauxin-activated signaling pathway1
GO:0009873 IEAUniProtethylene-activated signaling pathway1
GO:0016032 IEAUniProtviral process1
GO:0016567 IEAUniProtprotein ubiquitination1
GO:0007140 IMPGene Ontologymale meiotic nuclear division1
GO:0045910 IMPUniProtnegative regulation of DNA recombination1
GO:0046686 IEPUniProtresponse to cadmium ion1
GO:0000226 IMPUniProtmicrotubule cytoskeleton organization1
GO:0007346 IEAPLAZA Integrative Orthologyregulation of mitotic cell cycleAT3G21850

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004842 ISSGene Ontologyubiquitin-protein transferase activity1
GO:0005515 IPIGene Ontologyprotein binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634 IDA, ISM, NAS, UniProtnucleus1 2 3
GO:0005737 NASGene Ontologycytoplasm1
GO:0019005 NASGene OntologySCF ubiquitin ligase complex1
GO:0000151 TASGene Ontologyubiquitin ligase complex1
GO:0005819 IDAUniProtspindle1
GO:0009524 IDAUniProtphragmoplast1
GO:0005886 IDAUniProtplasma membrane1
GO:0005829 IDAUniProtcytosol1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR016073SKP1 component, POZ domain
IPR016072SKP1 component, dimerisation
IPR016897S-phase kinase-associated protein 1
IPR001232S-phase kinase-associated protein 1-like
IPR011333SKP1/BTB/POZ domain

Mapman id Description
19.2.2.8.1.1.Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.target protein binding component SKP1/ASK1
No SignalP domains detected for this gene.