Gene: AT1G63990 (Arabidopsis thaliana)

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Gene Identifier
AT1G63990
Transcript Identifier
AT1G63990.1
Gene Type
Coding gene
Location
Chr1 : 23743323-23745351 : negative

Family

Gene family
HOM04M001378
(107 genes in 29 species)
specific family
Subfamily
ORTHO04M007697
(33 genes in 28 species)
specific family

Descriptions

Description
sporulation 11-2
Curated Summary
Encodes AtSPO11-2, one of the three Arabidopsis homologues of the archaeal DNA topoisomerase VIA subunit (topo VIA). Required for meiotic recombination. Plants homozygous for atspo11-2 exhibit a severe sterility phenotype. Both male and female meiosis are severely disrupted in the atspo11-2 mutant, and this is associated with severe defects in synapsis during the first meiotic division and reduced meiotic recombination. AtSPO11-1 and AtSPO11-2 have overlapping functions (i.e. both required for meiotic recombination) whereas AtSPO11-3 functions in DNA replication. Required for double-strand break induction.
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Identifiers

Type Value
symbolSPO11-2
tidAT1G63990.1
UniProtQ9M4A1

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0000737 IEAUniProtDNA catabolic process, endonucleolytic1
GO:0006259 ISS, IEAGene OntologyDNA metabolic process1
GO:0000706 IBAUniProtmeiotic DNA double-strand break processing1
GO:0006265 ISSGene OntologyDNA topological change1
GO:0009553 IMPUniProtembryo sac development1
GO:0009555 IMPUniProtpollen development1
GO:0048316 IMPUniProtseed development1
GO:0048437 IMPGene Ontologyfloral organ development1
GO:0042138 IGIGene Ontologymeiotic DNA double-strand break formation1
GO:0051026 IMPUniProtchiasma assembly1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003677 IBA, IEAISS, UniProtDNA binding1 2
GO:0003824 IEAUniProtcatalytic activity
GO:0005524 IEA, ISS, UniProtATP binding1 2
GO:0003918 IBA, ISS, UniProtDNA topoisomerase type II (ATP-hydrolyzing) activity1 2
GO:0016889 IBAUniProtendodeoxyribonuclease activity, producing 3'-phosphomonoesters1
GO:0046872 IEAUniProtmetal ion binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005694 IEAUniProtchromosome
GO:0000228 IBAUniProtnuclear chromosome1
GO:0005634 ISMGene Ontologynucleus1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR034136Topoisomerase 6 subunit A/Spo11, TOPRIM domain
IPR011991Winged helix-turn-helix DNA-binding domain
IPR002815Spo11/DNA topoisomerase VI subunit A
IPR013049Spo11/DNA topoisomerase VI, subunit A, N-terminal

Mapman id Description
13.3.6.2.1.1.Cell cycle organisation.mitosis and meiosis.meiotic recombination.meiotic double strand break initiation.meiotic topoisomerase-VI complex.component a/SPO11
No SignalP domains detected for this gene.