Gene: AT1G54690 (Arabidopsis thaliana)

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Gene Identifier
AT1G54690
Transcript Identifier
AT1G54690.1
Gene Type
Coding gene
Location
Chr1 : 20414607-20415206 : negative

Family

Gene family
HOM04M000147
(594 genes in 29 species)
specific family
Subfamily
ORTHO04M000156
(387 genes in 29 species)
specific family

Descriptions

Description
gamma histone variant H2AX
Curated Summary
Encodes HTA3, a histone H2A protein. H2AX is a meiosis-specific isoform of histone H2A. Upon DSB formation, rapid accumulation of phosphorylated H2AX (γ-H2AX) occurs around the break site. H2AX foci accumulate in early G2. Immunolocalization studies in spread preparations of wild-type meiocytes at G2/early leptotene revealed the accumulation of numerous rather diffuse γ-H2AX foci throughout the chromatin. However, their accumulation is not contemporaneous with that of AtSPO11-1. At 3 h post-S, no γ-H2AX foci are detected. During the 3- to 5-h window when AtSPO11-1 foci rapidly disappear, there is an equally swift accumulation of γ-H2AX to a maximum of >50 diffuse foci. The level of γH2AX then remains constant for a further 13 h before undergoing a gradual decrease to 10–20 foci in the 18- to 24-h post-S period. By 30 h the foci have disappeared from the chromatin.
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Identifiers

Type Value
AliasG-H2AX,GAMMA H2AX,H2AXB,HTA3,histone H2A 3
symbolGAMMA-H2AX
tidAT1G54690.1
UniProtQ9S9K7

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006342 IBAGene Ontologychromatin silencing1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003677 IBA, ISS, IEAGene OntologyDNA binding1 2
GO:0046982 IEAGene Ontologyprotein heterodimerization activity1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0000786 IEAGene Ontologynucleosome1
GO:0005634 IDA, ISM, IEAGene Ontologynucleus1 2
GO:0000790 IBAGene Ontologynuclear chromatin1
GO:0005730 IDAGene Ontologynucleolus1

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR032454Histone H2A, C-terminal domain
IPR007125Histone H2A/H2B/H3
IPR002119Histone H2A
IPR032458Histone H2A conserved site
IPR009072Histone-fold

Mapman id Description
12.1.2.Chromatin organisation.histones.histone (H2A)
No SignalP domains detected for this gene.