Gene: AT1G15750 (Arabidopsis thaliana)

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Gene Identifier
AT1G15750
Transcript Identifier
AT1G15750.2
Gene Type
Coding gene
Location
Chr1 : 5415086-5420359 : negative

Family

Gene family
HOM04M000597
(208 genes in 27 species)
specific family
Subfamily
ORTHO04M000727
(151 genes in 27 species)
specific family
Duplication type
Block duplicate

Descriptions

Description
Transducin family protein / WD-40 repeat family protein
Curated Summary
Encodes a protein with several WD40 repeats at the C-terminus and predicted protein-protein interaction domains at the N-terminus. Together with the TOPLESS-RELATED PROTEINS (TPRs), it is thought to be involved in transcriptional repression of root-promoting genes in the top help of the embryo during the transition stage of embryogenesis. The ability of IAA12 to repress transcription is diminished in a tpl-1 mutant background.
Encodes a protein with several WD40 repeats at the C-terminus and predicted protein-protein interaction domains at the N-terminus. Together with the TOPLESS-RELATED PROTEINS (TPRs), it is thought to be involved in transcriptional repression of root-promoting genes in the top half of the embryo during the transition stage of embryogenesis. It can also interact with IAA12 through the EAR domain of IAA12 and the CTLH domain of TPL. The ability of IAA12 to repress transcription is diminished in a tpl-1 mutant background.
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Identifiers

Type Value
AliasWSIP1,WUS-INTERACTING PROTEIN 1
full_nameTOPLESS
symbolTPL
tidAT1G15750.2
UniProtQ94AI7

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006355 IEAInterProregulation of transcription, DNA-templated
GO:0006351 IEAUniProttranscription, DNA-templated1
GO:0010072 IMP, IGI, UniProtprimary shoot apical meristem specification1 2
GO:0009733 IPIUniProtresponse to auxin1
GO:0010051 IGIUniProtxylem and phloem pattern formation1
GO:0045892 IDAUniProtnegative regulation of transcription, DNA-templated1
GO:0009867 IMPUniProtjasmonic acid mediated signaling pathway1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005515 IPI, IEAGene Ontologyprotein binding1
GO:0042803 IPIUniProtprotein homodimerization activity1
GO:0051879 IEAPLAZA Integrative OrthologyHsp90 protein bindingAT1G80490

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634 IDA, ISM, UniProtnucleus1 2
GO:0005829 IDAUniProtcytosol1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR015943WD40/YVTN repeat-like-containing domain
IPR027728Topless family
IPR001680WD40 repeat
IPR019775WD40 repeat, conserved site
IPR006595CTLH, C-terminal LisH motif
IPR006594LIS1 homology motif
IPR017986WD40-repeat-containing domain

Mapman id Description
11.2.2.2.Phytohormone action.auxin.perception and signal transduction.transcriptional repressor (TPL)
15.5.53.1.RNA biosynthesis.transcriptional regulation.transcriptional repression.transcriptional co-repressor (TPL/TPR)
No SignalP domains detected for this gene.