Gene: AT1G08880 (Arabidopsis thaliana)

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Gene Identifier
AT1G08880
Transcript Identifier
AT1G08880.1
Gene Type
Coding gene
Location
Chr1 : 2847144-2847676 : negative

Family

Gene family
HOM04M000147
(594 genes in 29 species)
specific family
Subfamily
ORTHO04M000156
(387 genes in 29 species)
specific family

Descriptions

Description
Histone superfamily protein
Curated Summary
Encodes HTA5, a histone H2A protein. H2AX is a meiosis-specific isoform of histone H2A. Upon DSB formation, rapid accumulation of phosphorylated H2AX (γ-H2AX) occurs around the break site. H2AX foci accumulate in early G2. Immunolocalization studies in spread preparations of wild-type meiocytes at G2/early leptotene revealed the accumulation of numerous rather diffuse γ-H2AX foci throughout the chromatin. However, their accumulation is not contemporaneous with that of AtSPO11-1. At 3 h post-S, no γ-H2AX foci are detected. During the 3- to 5-h window when AtSPO11-1 foci rapidly disappear, there is an equally swift accumulation of γ-H2AX to a maximum of >50 diffuse foci. The level of γH2AX then remains constant for a further 13 h before undergoing a gradual decrease to 10–20 foci in the 18- to 24-h post-S period. By 30 h the foci have disappeared from the chromatin.
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Identifiers

Type Value
symbolH2AXA
tidAT1G08880.1
UniProtO04848

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006342 IBAGene Ontologychromatin silencing1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003677 IBA, ISS, IEAGene OntologyDNA binding1 2
GO:0046982 IEAGene Ontologyprotein heterodimerization activity1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0000786 IEAGene Ontologynucleosome1
GO:0005634 IDA, ISM, IEAGene Ontologynucleus1 2
GO:0000790 IBAGene Ontologynuclear chromatin1
GO:0005730 IEAPLAZA Integrative OrthologynucleolusAT1G54690

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR032454Histone H2A, C-terminal domain
IPR007125Histone H2A/H2B/H3
IPR002119Histone H2A
IPR032458Histone H2A conserved site
IPR009072Histone-fold

Mapman id Description
12.1.2.Chromatin organisation.histones.histone (H2A)
No SignalP domains detected for this gene.