Gene: AT1G02580 (Arabidopsis thaliana)

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Gene Identifier
AT1G02580
Transcript Identifier
AT1G02580.1
Gene Type
Coding gene
Location
Chr1 : 544796-548994 : positive

Family

Gene family
HOM04M001962
(79 genes in 29 species)
specific family
Duplication type
Block duplicate

Descriptions

Description
SET domain-containing protein
Curated Summary
Encodes a putative transcription factor MEDEA (MEA) that negatively regulates seed development in the absence of fertilization. Mutations in this locus result in embryo lethality. MEA is a Polycomb group gene that is imprinted in the endosperm. The maternal allele is expressed and the paternal allele is silent. MEA is controlled by DEMETER (DME), a DNA glycosylase required to activate MEA expression, and METHYLTRANSFERASE I (MET1), which maintains CG methylation at the MEA locus. MEA is involved in the negative regulation of its own imprinted gene expression; the effect is not only allele-specific but also dynamically regulated during seed development. In the ovule, the MEA transcripts are accumulated at their highest level before fertilization and gradually decrease after fertilization
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Identifiers

Type Value
AliasEMB173,EMBRYO DEFECTIVE 173,FIS1,FERTILIZATION INDEPENDENT SEED 1,SDG5,SET DOMAIN-CONTAINING PROTEIN 5
full_nameMEDEA
symbolMEA
tidAT1G02580.1
UniProtO65312

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006351 IEAUniProttranscription, DNA-templated1
GO:2000014 IMPUniProtregulation of endosperm development1
GO:0009646 IEPUniProtresponse to absence of light1
GO:0045892 IMPUniProtnegative regulation of transcription, DNA-templated1
GO:0006349 IMPUniProtregulation of gene expression by genetic imprinting1
GO:0048317 IGIUniProtseed morphogenesis1
GO:0048316 IEAUniProtseed development

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0018024 IEAUniProthistone-lysine N-methyltransferase activity1
GO:0005515 IPI, IEAGene Ontologyprotein binding1
GO:0003700 ISSUniProttranscription factor activity, sequence-specific DNA binding1
GO:0043565 IDAUniProtsequence-specific DNA binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0031519 IEAUniProtPcG protein complex1
GO:0005634 IDA, ISM, UniProtnucleus1 2

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR033498Histone-lysine N-methyltransferase MEDEA
IPR001214SET domain
IPR025778Histone-lysine N-methyltransferase, EZ
IPR026489CXC domain
IPR001005SANT/Myb domain
IPR033467Tesmin/TSO1-like CXC domain

Mapman id Description
12.3.3.1.1.4.Chromatin organisation.histone modifications.histone lysine methylation.PRC2 histone methylation complex.VRN/FIS/EMF core subcomplexes.catalytic component CLF|SWN|MEA
12.3.3.3.Chromatin organisation.histone modifications.histone lysine methylation.class-I histone methyltransferase (Ez)
No SignalP domains detected for this gene.