Gene: AT2G38440 (Arabidopsis thaliana)

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Gene Identifier
AT2G38440
Transcript Identifier
AT2G38440.1
Gene Type
Coding gene
Location
Chr2 : 16095550-16100851 : positive

Family

Gene family
HOM04D001666
(183 genes in 52 species)
specific family
Subfamily
ORTHO04D001746
(175 genes in 52 species)
specific family

Descriptions

Description
SCAR homolog 2
Curated Summary
Encodes a subunit of the WAVE complex. The WAVE complex is required for activation of ARP2/3 complex which functions in actin microfilament nucleation and branching. Mutations cause defects in both the actin and microtubule cytoskeletons that result in aberrant epidermal cell expansion. itb1 mutants showed irregularities in trichome branch positioning and expansion. The SHD domain of this protein binds to BRK1 and overexpression of the SHD domain results in a dominant negative phenotype.
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Identifiers

Type Value
AliasATSCAR2,SCAR HOMOLOG 2,DIS3,ITB1,IRREGULAR TRICHOME BRANCH1,WAVE4
symbolSCAR2
tidAT2G38440.1
UniProtQ5XPJ9

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0010090 IMP, TAS, UniProttrichome morphogenesis1 2
GO:0045010 TASUniProtactin nucleation1
GO:0016337 IMPUniProtsingle organismal cell-cell adhesion1
GO:0051127 IMP, ISS, UniProtpositive regulation of actin nucleation1 2
GO:0010091 IMPUniProttrichome branching1
GO:0030036 IMP, IEA, UniProtactin cytoskeleton organization1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003779 IEAUniProtactin binding1
GO:0005515 IPIGene Ontologyprotein binding1
GO:0003785 IEAPLAZA Tree-based Orthologyactin monomer bindingAT2G34150

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005737 IDA, ISM, UniProtcytoplasm1 2
GO:0005856 IEAUniProtcytoskeleton1
GO:0031209 ISS, TAS, UniProtSCAR complex1 2
GO:0005886 IDAUniProtplasma membrane1
GO:0071944 IEAPLAZA Tree-based Orthologycell peripheryAT2G34150
GO:0010287 IEAPLAZA Tree-based OrthologyplastoglobuleAT5G01730
GO:0016020 IEAPLAZA Tree-based OrthologymembraneAT2G34150
GO:0009507 IEAPLAZA Tree-based OrthologychloroplastAT5G01730
GO:0043229 IEAPLAZA Tree-based Orthologyintracellular organelleAT2G34150

Color Legend

Computational Reviewed Evidence
Electronic Evidence
Experimental Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR028288SCAR/WAVE family
IPR003124WH2 domain

Mapman id Description
20.2.2.2.4.Cytoskeleton organisation.microfilament network.actin polymerisation.SCAR/WAVE ARP2/3-activating complex.component SCAR
No SignalP domains detected for this gene.