Gene: AT5G46210 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT5G46210
Transcript Identifier
AT5G46210.1
Gene Type
Coding gene
Location
Chr5 : 18731569-18736653 : negative

Family Information

Homologous gene family
HOM04x5M000423
(437 genes in 39 species)
specific family
Orthologous gene family
ORTHO04x5M005888
(59 genes in 39 species)
specific family

Descriptions

Description
cullin4
Curated Summary
Arabidopsis CULLIN4 (CUL4) forms an E3 ubiquitin ligase with the CDD complex and a common catalytic subunit RBX1 in mediating light control of development. This CUL4-based E3 ligase is essential for the repression of photomorphogenesis. The partial loss of CUL4 function resulted in a constitutive photomorphogenic phenotype with respect to morphogenesis and light-regulated gene expression. CUL4 exhibits a synergistic genetic interaction with COP10 and DET1.
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Identifiers

Type Value
AliasATCUL4
DbxrefPMID:12795696,PMID:16844902,PMID:17307927,PMID:18223036,PMID:18434413,PMID:18552200,gene:3440904,UniProt:Q8LGH4
symbolCUL4
tidAT5G46210.1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006511
IBA
Gene Ontologyubiquitin-dependent protein catabolic process1
GO:0006511
IEA
InterProubiquitin-dependent protein catabolic process
GO:0009738
IEA
Gene Ontologyabscisic acid-activated signaling pathway2
GO:0009640
IMP
Gene Ontologyphotomorphogenesis3 4
GO:0048366
IMP
Gene Ontologyleaf development3 4
GO:0000209
IDA
Gene Ontologyprotein polyubiquitination5 6
GO:0009908
IMP
Gene Ontologyflower development5 6
GO:0010100
IMP
Gene Ontologynegative regulation of photomorphogenesis5 6
GO:0048367
IMP
Gene Ontologyshoot system development5 6
GO:0009755
IMP
Gene Ontologyhormone-mediated signaling pathway7 8
GO:0010154
IMP
Gene Ontologyfruit development7 8
GO:0010182
IMP
Gene Ontologysugar mediated signaling pathway7 8
GO:0048825
IMP
Gene Ontologycotyledon development7 8
GO:0006281
IMP
Gene OntologyDNA repair9 10
GO:0048575
IMP
Gene Ontologyshort-day photoperiodism, flowering11 12
GO:0031146
IBA
Gene OntologySCF-dependent proteasomal ubiquitin-dependent protein catabolic process1
GO:0043161
IBA
Gene Ontologyproteasome-mediated ubiquitin-dependent protein catabolic process1

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0031625
IBA
Gene Ontologyubiquitin protein ligase binding1
GO:0031625
IEA
InterProubiquitin protein ligase binding
GO:0005515
IPI
Gene Ontologyprotein binding13 14

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0031461
IBA
Gene Ontologycullin-RING ubiquitin ligase complex1
GO:0031461
IEA
InterProcullin-RING ubiquitin ligase complex
GO:0009507
ISM
Gene Ontologychloroplast15
GO:0080008
IPI
IBA
Gene OntologyCul4-RING E3 ubiquitin ligase complex1 3 4
GO:0000151
IPI
Gene Ontologyubiquitin ligase complex5 6
GO:0005634
IDA
Gene Ontologynucleus5 6
GO:0005829
IDA
Gene Ontologycytosol16 17
GO:0019005
IBA
Gene OntologySCF ubiquitin ligase complex1

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR036388Winged helix-like DNA-binding domain superfamily
IPR033044Cullin-4B
IPR001373Cullin, N-terminal
IPR019559Cullin protein, neddylation domain
IPR016157Cullin, conserved site
IPR016158Cullin homology domain
IPR016159Cullin repeat-like-containing domain superfamily
IPR036390Winged helix DNA-binding domain superfamily
IPR036317Cullin homology domain superfamily

Mapman id Description
19.2.2.8.3.1Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.scaffold component CUL4
26.1.1.3.1External stimuli response.light.red/far red light.CUL4-DDB1 ubiquitination complex.scaffold component (CUL4)