Gene: AT2G39800 (Arabidopsis thaliana)

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Gene Identifier
AT2G39800
Transcript Identifier
AT2G39800.1
Gene Type
Coding gene
Location
Chr2 : 16598516-16602939 : negative

Family Information

Homologous gene family
HOM04x5M002076
(120 genes in 39 species)
specific family
Orthologous gene family
ORTHO04x5M002747
(101 genes in 39 species)
specific family
Duplication type
Block duplicate

Descriptions

Description
delta1-pyrroline-5-carboxylate synthase 1
Curated Summary
encodes a delta1-pyrroline-5-carboxylate synthase that catalyzes the rate-limiting enzyme in the biosynthesis of proline. Gene is expressed in reproductive organs and tissues under non-stress conditions but in the whole plant under water-limiting condition. Expression is also induced by abscisic acid and salt stress in a light-dependent manner. encodes a delta1-pyrroline-5-carboxylate synthase that catalyzes the rate-limiting enzyme in the biosynthesis of proline. Gene is expressed in reproductive organs and tissues under non-stress conditions but in the whole plant under water-limiting condition. Expression is also induced by abscisic acid and salt stress in a light-dependent manner. P5CS1 appears to be involved in salt stress responses related to proline accumulation, including protection from reactive oxidative species. P5CS1 appears to be present in different cells and/or different subcellular locations from P5CS2 in a tissue-dependent manner.
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Identifiers

Type Value
AliasATP5CS
DbxrefPMID:7773306,PMID:17432890,PMID:18552355,gene:2063906,UniProt:P54887
symbolP5CS1
tidAT2G39800.1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006561
IMP
TAS, IEA
Gene Ontologyproline biosynthetic process1 2 3 4 5
GO:0006561
IEA
InterProproline biosynthetic process
GO:0055114
IEA
Gene Ontologyoxidation-reduction process6
GO:0055114
IEA
InterProoxidation-reduction process
GO:0016310
IEA
Gene Ontologyphosphorylation6
GO:0055129
IEA
Gene OntologyL-proline biosynthetic process7
GO:0009414
IGI, IEP
Gene Ontologyresponse to water deprivation2 3 8 9
GO:0006979
IMP
Gene Ontologyresponse to oxidative stress4 5
GO:0042538
IMP, IEP
Gene Ontologyhyperosmotic salinity response4 5 10 11
GO:0048364
IMP
Gene Ontologyroot development4 5
GO:0009555
IMP
Gene Ontologypollen development12 13
GO:0009269
IEP
Gene Ontologyresponse to desiccation10 11
GO:0009651
IEP
Gene Ontologyresponse to salt stress10 11
GO:0009737
IEP
Gene Ontologyresponse to abscisic acid10 11
GO:0009793
ISO
PLAZA Integrative Orthologyembryo development ending in seed dormancy AT3G55610

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004350
IEA
Gene Ontologyglutamate-5-semialdehyde dehydrogenase activity1
GO:0004350
IEA
InterProglutamate-5-semialdehyde dehydrogenase activity
GO:0016491
IEA
InterProoxidoreductase activity
GO:0016620
IEA
InterProoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0003824
IEA
InterProcatalytic activity
GO:0004349
IEA
Gene Ontologyglutamate 5-kinase activity14
GO:0004349
IEA
InterProglutamate 5-kinase activity
GO:0005524
IEA
Gene OntologyATP binding6
GO:0017084
ISS
Gene Ontologydelta1-pyrroline-5-carboxylate synthetase activity2 3

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
ISM
Gene Ontologycytoplasm4 5 15
GO:0005737
IEA
InterProcytoplasm
GO:0005739
ISM
Gene Ontologymitochondrion15
GO:0016020
IDA
Gene Ontologymembrane16 17
GO:0009507
IDA
Gene Ontologychloroplast4 5
GO:0009506
ISO
PLAZA Integrative Orthologyplasmodesma AT3G55610
GO:0005829
ISO
PLAZA Integrative Orthologycytosol AT3G55610

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000965GPR domain
IPR016162Aldehyde dehydrogenase, N-terminal
IPR016163Aldehyde dehydrogenase, C-terminal
IPR036393Acetylglutamate kinase-like superfamily
IPR005715Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase
IPR015590Aldehyde dehydrogenase domain
IPR001048Aspartate/glutamate/uridylate kinase
IPR005766Delta l-pyrroline-5-carboxylate synthetase
IPR001057Glutamate/acetylglutamate kinase
IPR019797Glutamate 5-kinase, conserved site
IPR020593Gamma-glutamyl phosphate reductase GPR, conserved site
IPR016161Aldehyde/histidinol dehydrogenase

Mapman id Description
4.1.1.1.4.1.1Amino acid metabolism.biosynthesis.glutamate family.glutamate-derived amino acids.proline.main pathway.pyrroline-5-carboxylate synthetase