Gene: AT1G63990 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT1G63990
Transcript Identifier
AT1G63990.1
Gene Type
Coding gene
Location
Chr1 : 23743323-23745351 : negative

Family Information

Homologous gene family
HOM04x5M001015
(217 genes in 39 species)
specific family
Orthologous gene family
ORTHO04x5M008027
(49 genes in 38 species)
specific family

Descriptions

Description
sporulation 11-2
Curated Summary
Encodes AtSPO11-2, one of the three Arabidopsis homologues of the archaeal DNA topoisomerase VIA subunit (topo VIA). Required for meiotic recombination. Plants homozygous for atspo11-2 exhibit a severe sterility phenotype. Both male and female meiosis are severely disrupted in the atspo11-2 mutant, and this is associated with severe defects in synapsis during the first meiotic division and reduced meiotic recombination. AtSPO11-1 and AtSPO11-2 have overlapping functions (i.e. both required for meiotic recombination) whereas AtSPO11-3 functions in DNA replication. Required for double-strand break induction.
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Identifiers

Type Value
DbxrefPMID:17018031,gene:2024597,UniProt:Q9M4A1
symbolSPO11-2
tidAT1G63990.1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006259
ISS
Gene OntologyDNA metabolic process1
GO:0006259
IEA
InterProDNA metabolic process
GO:0000737
IEA
InterProDNA catabolic process, endonucleolytic
GO:0006265
ISS
Gene OntologyDNA topological change1
GO:0009553
IMP
Gene Ontologyembryo sac development2 3
GO:0009555
IMP
Gene Ontologypollen development2 3
GO:0048316
IMP
Gene Ontologyseed development2 3
GO:0048437
IMP
Gene Ontologyfloral organ development2 3
GO:0051321
IMP
Gene Ontologymeiotic cell cycle2 3
GO:0042138
IGI
IBA
Gene Ontologymeiotic DNA double-strand break formation4 5 6
GO:0051026
IMP
Gene Ontologychiasma assembly7 8
GO:0007131
IBA
Gene Ontologyreciprocal meiotic recombination4
GO:0000706
IBA
Gene Ontologymeiotic DNA double-strand break processing4

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003677
ISS, IBA
IEA
Gene OntologyDNA binding1 4 9
GO:0003677
IEA
InterProDNA binding
GO:0016889
IBA
Gene Ontologyendodeoxyribonuclease activity, producing 3'-phosphomonoesters4
GO:0016889
IEA
InterProendodeoxyribonuclease activity, producing 3'-phosphomonoesters
GO:0003824
IEA
Gene Ontologycatalytic activity9
GO:0003824
IEA
InterProcatalytic activity
GO:0005524
ISS
IEA
Gene OntologyATP binding1 9
GO:0005524
IEA
InterProATP binding
GO:0003918
ISS
IEA
Gene OntologyDNA topoisomerase type II (ATP-hydrolyzing) activity1 10
GO:0046872
IEA
Gene Ontologymetal ion binding11
GO:0005515
IPI
Gene Ontologyprotein binding12 13

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005694
IEA
Gene Ontologychromosome9
GO:0005694
IEA
InterProchromosome
GO:0005634
ISM
IEA
Gene Ontologynucleus14 15

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR034136Topoisomerase 6 subunit A/Spo11, TOPRIM domain
IPR036388Winged helix-like DNA-binding domain superfamily
IPR002815Spo11/DNA topoisomerase VI subunit A
IPR013049Spo11/DNA topoisomerase VI, subunit A, N-terminal
IPR036078Spo11/DNA topoisomerase VI subunit A superfamily

Mapman id Description
13.3.6.2.1.1Cell cycle organisation.mitosis and meiosis.meiotic recombination.meiotic double strand break initiation.meiotic topoisomerase-VI complex.component a/SPO11