Gene: AT1G08130 (Arabidopsis thaliana)

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Gene Identifier
AT1G08130
Transcript Identifier
AT1G08130.1
Gene Type
Coding gene
Location
Chr1 : 2542913-2547815 : negative

Family Information

Homologous gene family
HOM04x5M001747
(137 genes in 39 species)
specific family
Orthologous gene family
ORTHO04x5M002018
(123 genes in 39 species)
specific family

Descriptions

Description
DNA ligase 1
Curated Summary
Encodes the Arabidopsis DNA ligase 1 that provides the major DNA ligase activity in cells and plays a key role in both DNA replication and excision repair pathways. Indispensable for cell viability. AtLIG1 expresses one major and two minor mRNA transcripts differing only in the length of the 5' untranslated leader sequences preceding a common ORF. Translation from the first in-frame start codon produces an AtLIG1 isoform that is targeted exclusively to the mitochondria. Translation initiation from the second in-frame start codon produces an AtLIG1 isoform targeted only to the nucleus.
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Identifiers

Type Value
AliasATLIG1,DNA ligase 1
Dbxrefgene:3435770,UniProt:Q42572
symbolLIG1
tidAT1G08130.1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006281
IEA
InterProDNA repair
GO:0006310
IEA
Gene OntologyDNA recombination1
GO:0006310
IEA
InterProDNA recombination
GO:0051103
IEA
Gene OntologyDNA ligation involved in DNA repair2
GO:0051103
IEA
InterProDNA ligation involved in DNA repair
GO:0071897
IEA
Gene OntologyDNA biosynthetic process2
GO:0071897
IEA
InterProDNA biosynthetic process
GO:0007049
IEA
Gene Ontologycell cycle1
GO:0051301
IEA
Gene Ontologycell division1
GO:0000012
IMP
Gene Ontologysingle strand break repair3 4
GO:0006260
IMP
Gene OntologyDNA replication3 4
GO:0006302
IMP
Gene Ontologydouble-strand break repair3 4
GO:0080111
IMP
Gene OntologyDNA demethylation5 6
GO:0006273
IBA
Gene Ontologylagging strand elongation7

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003677
IEA
Gene OntologyDNA binding2
GO:0003677
IEA
InterProDNA binding
GO:0003910
ISS, IBA
Gene OntologyDNA ligase (ATP) activity7 8
GO:0003910
IEA
InterProDNA ligase (ATP) activity
GO:0005524
ISS
IEA
Gene OntologyATP binding1 8
GO:0005524
IEA
InterProATP binding
GO:0003909
IEA
InterProDNA ligase activity
GO:0046872
IEA
Gene Ontologymetal ion binding1

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
ISM, IBA
Gene Ontologynucleus7 9 10 11
GO:0005739
IDA
IBA
Gene Ontologymitochondrion7 10 11
GO:0005730
IDA
Gene Ontologynucleolus5 6
GO:0005737
IBA
Gene Ontologycytoplasm7

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR036599DNA ligase, ATP-dependent, N-terminal domain superfamily
IPR012310DNA ligase, ATP-dependent, central
IPR012309DNA ligase, ATP-dependent, C-terminal
IPR012308DNA ligase, ATP-dependent, N-terminal
IPR016059DNA ligase, ATP-dependent, conserved site
IPR012340Nucleic acid-binding, OB-fold
IPR000977DNA ligase, ATP-dependent

Mapman id Description
13.2.4.3Cell cycle organisation.DNA replication.maturation.DNA ligase (LIG1)
14.5.5DNA damage response.base excision repair (BER).DNA ligase (LIG1)