This entry represents a family of uridine kinase proteins [1].

Uridine kinase (pyrimidine ribonucleoside kinase) is the rate-limiting enzyme in the pyrimidine salvage pathway. It catalyses the following reaction:

A cDNA for uridine kinase from mouse brain was found which encodes a protein of 277 amino acids. A truncated form of the cDNA was expressed in Escherichia coli, and shown to display uridinekinase activity and to readily form a tetramer, the most active form of the wild-type enzyme. Sequence analysis has identified three ATP-binding site consensus motifs. The predicted secondary structure, and sequence comparison with kinases of known structure, is consistent with uridine kinase having the alpha/beta core nucleotide-binding fold common to many kinases [2].

1. Uracil salvage is necessary for early Arabidopsis development. Plant J. 60, 280-91
2. Cloning and expression of a cDNA encoding uridine kinase from mouse brain. Arch. Biochem. Biophys. 336, 105-12

This entry represents a family of uridine kinase proteins [1].

Urid
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