This entry represents domains related by a common ancestor that have a Rossmann-like, 3-layer, alpha/beta/alpha sandwich fold. Protein families in which the domain is found include:

• Nucleotidylyl transferases (2.7.7) such as cytidylyltransferases [1], adenylyltransferases [2].
• Class I aminoacyl-tRNA synthetases (catalytic domain), such as tyrosyl-tRNA synthetase (6.1.1.1) and glutaminyl-tRNA synthetase (6.1.1.18) [3].
• Pantothenate synthetases (6.3.2.1) [4].
• ATP sulphurylase (central domain) [5]
• N-type ATP pyrophosphatases, such as beta-lactam synthetase (6.3.3.4) and GMP synthase (6.3.5.2) [6].
• PP-loop ATPases such as the cell cycle protein MesJ (N-terminal domain) [7].
• Phosphoadenylyl sulphate (PAPS) reductase [8]
• Electron transfer flavoprotein (ETFP) subunits, such as the N-terminal domains of the alpha and beta subunits [9].
• Universal stress protein A (UspA) [10].
• Cryptochrome and DNA photolyase [11].

1. Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: examination of structural basis for kinetic mechanism. Biochim. Biophys. Acta 1764, 63-9
2. Structure and implications for the thermal stability of phosphopantetheine adenylyltransferase from Thermus thermophilus. Acta Crystallogr. D Biol. Crystallogr. 60, 97-104
3. Architectures of class-defining and specific domains of glutamyl-tRNA synthetase. Science 267, 1958-65
4. Crystal structure of the pantothenate synthetase from Mycobacterium tuberculosis, snapshots of the enzyme in action. Biochemistry 45, 1554-61
5. Molecular basis for G protein control of the prokaryotic ATP sulfurylase. Mol. Cell 21, 109-22
6. The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families. Nat. Struct. Biol. 3, 74-86
7. Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain. Proc. Natl. Acad. Sci. U.S.A. 102, 7487-92
8. Crystal structure of phosphoadenylyl sulphate (PAPS) reductase: a new family of adenine nucleotide alpha hydrolases. Structure 5, 895-906
9. Three-dimensional structure of human electron transfer flavoprotein to 2.1-A resolution. Proc. Natl. Acad. Sci. U.S.A. 93, 14355-60
10. The Pseudomonas aeruginosa universal stress protein PA4352 is essential for surviving anaerobic energy stress. J. Bacteriol. 188, 6529-38
11. Crystal structure of cryptochrome 3 from Arabidopsis thaliana and its implications for photolyase activity. Proc. Natl. Acad. Sci. U.S.A. 103, 17701-6

This entry represents domains related by a common ancestor that have a Rossmann-like, 3-layer,
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