This entry represents domains with a double-stranded beta-helix jelly roll fold such as that found in RmlC (deoxythymidine diphosphates-4-dehydrorhamnose 3,5-epimerase; 5.1.3.13), a dTDP-sugar isomerase enzyme involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria [1].

Other protein families contain domains that share this jelly roll fold, including glucose-6-phosphate isomerase (5.3.1.9); germin, a metal-binding protein with oxalate oxidase and superoxide dismutases activities [2]; auxin-binding protein [3]; seed storage protein 7S [4]; acireductone dioxygenase [5]; as well as three proteins that have metal-binding sites similar to that of germine, namely quercetin 2,3-dioxygenase (1.13.11.24) [6], phosphomannose isomerase (5.3.1.8) [7] and homogentisate dioxygenase (1.13.11.5) [8], the last three sharing a 2-domain fold with storage protein 7s.

The cAMP-binding domains found in the cAMP receptor protein (CRP) family display a similar double-stranded beta-helix jelly roll fold. These proteins include CooA, a CO-sensing haem protein that functions as a transcription activator [9], and the CnbD (cyclic nucleotide binding domain) of the HCN cation channel in which cAMP binding modulates gating of the channel [10].

1. RmlC, the third enzyme of dTDP-L-rhamnose pathway, is a new class of epimerase. Nat. Struct. Biol. 7, 398-402
2. Germin is a manganese containing homohexamer with oxalate oxidase and superoxide dismutase activities. Nat. Struct. Biol. 7, 1036-40
3. Crystal structure of auxin-binding protein 1 in complex with auxin. EMBO J. 21, 2877-85
4. Crystal structure of soybean proglycinin A1aB1b homotrimer. J. Mol. Biol. 305, 291-305
5. Modeling and experiment yields the structure of acireductone dioxygenase from Klebsiella pneumoniae. Nat. Struct. Biol. 9, 966-72
6. Crystal structure of the copper-containing quercetin 2,3-dioxygenase from Aspergillus japonicus. Structure 10, 259-68
7. The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution. Nat. Struct. Biol. 3, 470-9
8. Crystal structure of human homogentisate dioxygenase. Nat. Struct. Biol. 7, 542-6
9. Transcription activation by CooA, the CO-sensing factor from Rhodospirillum rubrum. The interaction between CooA and the C-terminal domain of the alpha subunit of RNA polymerase. J. Biol. Chem. 274, 10840-5
10. cAMP Modulation of the cytoplasmic domain in the HCN2 channel investigated by molecular simulations. Biophys. J. 90, 3428-33

This entry represents domains with a double-stranded beta-helix jelly roll fold such as that foun
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